Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 717821..718514 Replicon chromosome
Accession NZ_CP123963
Organism Escherichia coli strain L6-21

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QC817_RS03530 Protein ID WP_000415584.1
Coordinates 717821..718117 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QC817_RS03535 Protein ID WP_000650107.1
Coordinates 718119..718514 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC817_RS03495 (712909) 712909..713223 - 315 WP_000958598.1 putative quinol monooxygenase -
QC817_RS03500 (713254) 713254..713835 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QC817_RS03505 (714154) 714154..714486 + 333 WP_000917684.1 DUF2645 family protein -
QC817_RS03510 (714532) 714532..715881 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
QC817_RS03515 (715878) 715878..716537 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QC817_RS03520 (716689) 716689..717081 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QC817_RS03525 (717134) 717134..717616 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QC817_RS03530 (717821) 717821..718117 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QC817_RS03535 (718119) 718119..718514 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QC817_RS03540 (718647) 718647..720254 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QC817_RS03545 (720392) 720392..722650 + 2259 WP_032161229.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T279271 WP_000415584.1 NZ_CP123963:717821-718117 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT279271 WP_000650107.1 NZ_CP123963:718119-718514 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References