Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 610798..611597 Replicon chromosome
Accession NZ_CP123963
Organism Escherichia coli strain L6-21

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QC817_RS02995 Protein ID WP_000347273.1
Coordinates 610798..611262 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QC817_RS03000 Protein ID WP_001307405.1
Coordinates 611262..611597 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC817_RS02965 (605799) 605799..606233 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QC817_RS02970 (606251) 606251..607129 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
QC817_RS02975 (607119) 607119..607898 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QC817_RS02980 (607909) 607909..608382 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QC817_RS02985 (608405) 608405..609685 - 1281 WP_127446705.1 tagatose-bisphosphate aldolase subunit KbaZ -
QC817_RS02990 (609934) 609934..610743 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QC817_RS02995 (610798) 610798..611262 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QC817_RS03000 (611262) 611262..611597 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QC817_RS03005 (611746) 611746..613317 - 1572 WP_072645938.1 galactarate dehydratase -
QC817_RS03010 (613692) 613692..615026 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
QC817_RS03015 (615042) 615042..615812 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T279269 WP_000347273.1 NZ_CP123963:c611262-610798 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT279269 WP_001307405.1 NZ_CP123963:c611597-611262 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References