Detailed information of TA system TA027926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 1145858..1146394
• Replicon: chromosome
• Accession: NC_018024
• Organism: Anaerobaculum mobile DSM 13181

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: I4BWY0
• Locus tag: ANAMO_RS05800
• Protein ID: WP_014807017.1
• Coordinates: 1146122..1146394 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: I4BWX9
• Locus tag: ANAMO_RS05795
• Protein ID: WP_014807016.1
• Coordinates: 1145858..1146121 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANAMO_RS05770	1140896..1142056	+	1161	WP_052312707.1	ATP-binding protein	-
ANAMO_RS05775	1142184..1144037	-	1854	WP_041459774.1	cadmium-translocating P-type ATPase	-
ANAMO_RS05780	1144040..1144261	-	222	WP_041459775.1	heavy-metal-associated domain-containing protein	-
ANAMO_RS05785	1144548..1144913	+	366	WP_009200783.1	metalloregulator ArsR/SmtB family transcription factor	-
ANAMO_RS05790	1145007..1145714	-	708	WP_014807015.1	hypothetical protein	-
ANAMO_RS05795	1145858..1146121	+	264	WP_014807016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ANAMO_RS05800	1146122..1146394	+	273	WP_014807017.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ANAMO_RS05805	1146514..1146735	-	222	WP_014807018.1	type II toxin-antitoxin system HicA family toxin	-
ANAMO_RS05810	1146719..1146964	-	246	WP_014807019.1	type II toxin-antitoxin system HicB family antitoxin	-
ANAMO_RS05815	1147132..1147368	-	237	WP_014807020.1	DUF4351 domain-containing protein	-
ANAMO_RS05820	1147740..1147961	+	222	WP_014807021.1	DUF2281 domain-containing protein	-
ANAMO_RS05825	1148397..1149392	-	996	WP_014807022.1	electron transfer flavoprotein subunit alpha/FixB family protein	-
ANAMO_RS05830	1149389..1150171	-	783	WP_014807023.1	electron transfer flavoprotein subunit beta/FixA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-82)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10837.54 Da
• Isoelectric Point: 9.9945

>T27926 WP_014807017.1 NC_018024:1146122-1146394 [Acetomicrobium mobile DSM 13181]
MLDIRYSSQFKKDIRRLKRQGKDLEKLREAILLLAKGEALLAHYLDHSLRGQWNKYREIHIDNDWLLIYRKTEKELLLVS
TGSHSELFDR

Nucleotide

• Length: 273 bp

>T27926 NC_018024:1146122-1146394 [Acetomicrobium mobile DSM 13181]
ATGTTAGATATTCGATACTCTTCGCAGTTCAAAAAGGATATTCGTCGTCTAAAAAGGCAGGGCAAAGATTTGGAAAAATT
ACGAGAGGCGATTTTGCTCCTTGCCAAAGGAGAAGCTTTGCTAGCACATTATTTAGATCACTCTTTACGTGGGCAGTGGA
ATAAGTATCGAGAAATTCATATTGATAACGATTGGCTTCTTATATACAGAAAAACAGAAAAAGAGCTGCTTTTAGTTTCA
ACCGGTTCACATTCAGAACTTTTTGATCGATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9637.09 Da
• Isoelectric Point: 7.9921

>AT27926 WP_014807016.1 NC_018024:1145858-1146121 [Acetomicrobium mobile DSM 13181]
MRRVCDSSIRVRIDSDTKERASKALDRMGLSISDAVRLLLVRIAEDGRFPFDLEVPNARTRKAMVELEEGGGISKTSIKD
AFADLGL

Nucleotide

• Length: 264 bp

>AT27926 NC_018024:1145858-1146121 [Acetomicrobium mobile DSM 13181]
TTGAGGCGCGTTTGCGATTCGTCGATTCGGGTAAGAATAGACAGCGACACAAAAGAGCGAGCATCAAAAGCGCTGGACAG
GATGGGCCTTTCGATCTCTGATGCTGTGCGTTTGCTATTGGTTCGAATAGCCGAAGATGGTCGATTTCCCTTCGATCTAG
AGGTACCAAACGCCAGAACGAGAAAGGCAATGGTCGAGCTTGAAGAAGGAGGCGGAATATCTAAAACTTCCATCAAAGAT
GCGTTTGCAGATTTAGGACTCTAA

Structures

Toxin

• AlphaFold DB: I4BWY0

Antitoxin

• AlphaFold DB: I4BWX9