Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1987987..1988680 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QGM68_RS09550 Protein ID WP_000415584.1
Coordinates 1987987..1988283 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QGM68_RS09555 Protein ID WP_000650107.1
Coordinates 1988285..1988680 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS09515 (1983075) 1983075..1983389 - 315 WP_000958598.1 putative quinol monooxygenase -
QGM68_RS09520 (1983420) 1983420..1984001 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QGM68_RS09525 (1984320) 1984320..1984652 + 333 WP_000917684.1 DUF2645 family protein -
QGM68_RS09530 (1984698) 1984698..1986047 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QGM68_RS09535 (1986044) 1986044..1986703 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QGM68_RS09540 (1986855) 1986855..1987247 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QGM68_RS09545 (1987300) 1987300..1987782 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QGM68_RS09550 (1987987) 1987987..1988283 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QGM68_RS09555 (1988285) 1988285..1988680 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QGM68_RS09560 (1988813) 1988813..1990420 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QGM68_RS09565 (1990558) 1990558..1992816 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T279232 WP_000415584.1 NZ_CP123951:1987987-1988283 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT279232 WP_000650107.1 NZ_CP123951:1988285-1988680 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References