Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 313751..314445 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag QGM68_RS01510 Protein ID WP_001263493.1
Coordinates 313751..314149 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag QGM68_RS01515 Protein ID WP_152927302.1
Coordinates 314152..314445 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (308809) 308809..308889 - 81 NuclAT_8 - -
- (308809) 308809..308889 - 81 NuclAT_8 - -
- (308809) 308809..308889 - 81 NuclAT_8 - -
- (308809) 308809..308889 - 81 NuclAT_8 - -
QGM68_RS01480 (309485) 309485..309943 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QGM68_RS01485 (310204) 310204..311661 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
QGM68_RS01490 (311718) 311718..312239 - 522 Protein_293 peptide chain release factor H -
QGM68_RS01495 (312238) 312238..312441 - 204 Protein_294 RtcB family protein -
QGM68_RS01505 (313451) 313451..313741 - 291 Protein_296 GNAT family N-acetyltransferase -
QGM68_RS01510 (313751) 313751..314149 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QGM68_RS01515 (314152) 314152..314445 - 294 WP_152927302.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QGM68_RS01520 (314497) 314497..315552 - 1056 WP_001226164.1 DNA polymerase IV -
QGM68_RS01525 (315623) 315623..316408 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
QGM68_RS01530 (316380) 316380..318092 + 1713 Protein_301 flagellar biosynthesis protein FlhA -
QGM68_RS01535 (318316) 318316..318813 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 312699..313202 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T279226 WP_001263493.1 NZ_CP123951:c314149-313751 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11180.76 Da        Isoelectric Point: 5.2168

>AT279226 WP_152927302.1 NZ_CP123951:c314445-314152 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKACFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EXB8

Antitoxin

Source ID Structure

References