Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1778693..1779284 Replicon chromosome
Accession NZ_CP123909
Organism Pseudomonas atacamensis strain MGMM4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QG303_RS08285 Protein ID WP_281121056.1
Coordinates 1779006..1779284 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A4Q4L7P5
Locus tag QG303_RS08280 Protein ID WP_039757791.1
Coordinates 1778693..1778998 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG303_RS08250 (QG303_08250) 1774218..1774925 + 708 WP_281121055.1 HAD family hydrolase -
QG303_RS08255 (QG303_08255) 1775143..1775469 - 327 WP_016772583.1 transcriptional regulator SutA -
QG303_RS08260 (QG303_08260) 1775571..1775996 - 426 WP_024014775.1 secondary thiamine-phosphate synthase enzyme YjbQ -
QG303_RS08265 (QG303_08265) 1776211..1777548 - 1338 WP_041476939.1 ammonium transporter -
QG303_RS08270 (QG303_08270) 1777586..1777924 - 339 WP_002555808.1 P-II family nitrogen regulator -
QG303_RS08275 (QG303_08275) 1778319..1778579 + 261 WP_122603430.1 accessory factor UbiK family protein -
QG303_RS08280 (QG303_08280) 1778693..1778998 - 306 WP_039757791.1 HigA family addiction module antitoxin Antitoxin
QG303_RS08285 (QG303_08285) 1779006..1779284 - 279 WP_281121056.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG303_RS08290 (QG303_08290) 1779610..1781103 + 1494 WP_016772579.1 YifB family Mg chelatase-like AAA ATPase -
QG303_RS08295 (QG303_08295) 1781100..1782314 - 1215 WP_122612288.1 aldose 1-epimerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilH / pilG / pilT / algR 1585917..1782981 197064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10415.98 Da        Isoelectric Point: 7.7181

>T279210 WP_281121056.1 NZ_CP123909:c1779284-1779006 [Pseudomonas atacamensis]
MIVSFRCPETEYLFRSGKTRFWSAILSVAERKLTMLDAAAALADLRSPPGNRLESLGGDRKGQCSIRINAQWRICFLWGL
NGPEDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11232.97 Da        Isoelectric Point: 6.4556

>AT279210 WP_039757791.1 NZ_CP123909:c1778998-1778693 [Pseudomonas atacamensis]
MTKNGMRPVHPGEILKEEYLEPLSLTAAALARALSVSTPTVNDIVLQRRGISADMALRLSICLDTTPEFWLNLQSTYDLR
KAEIERGAAIRDQVERLAHCA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q4L7P5

References