279207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1123555..1124135 Replicon chromosome
Accession NZ_CP123909
Organism Pseudomonas atacamensis strain MGMM4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QG303_RS05160 Protein ID WP_281121480.1
Coordinates 1123555..1123833 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QG303_RS05165 Protein ID WP_016773085.1
Coordinates 1123848..1124135 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG303_RS05140 (QG303_05140) 1119045..1119212 - 168 WP_016773090.1 DUF2474 domain-containing protein -
QG303_RS05145 (QG303_05145) 1119290..1120297 - 1008 WP_016773089.1 cytochrome d ubiquinol oxidase subunit II -
QG303_RS05150 (QG303_05150) 1120301..1121746 - 1446 WP_024014409.1 cytochrome ubiquinol oxidase subunit I -
QG303_RS05155 (QG303_05155) 1122220..1123455 + 1236 WP_016773087.1 MFS transporter -
QG303_RS05160 (QG303_05160) 1123555..1123833 + 279 WP_281121480.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG303_RS05165 (QG303_05165) 1123848..1124135 + 288 WP_016773085.1 HigA family addiction module antitoxin Antitoxin
QG303_RS05170 (QG303_05170) 1124140..1124691 - 552 WP_016773084.1 DJ-1/PfpI family protein -
QG303_RS05175 (QG303_05175) 1124759..1125205 - 447 WP_281121481.1 DUF4879 domain-containing protein -
QG303_RS05180 (QG303_05180) 1125426..1126721 + 1296 WP_071173664.1 NCS2 family permease -
QG303_RS05185 (QG303_05185) 1126718..1127797 + 1080 WP_258710563.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
QG303_RS05190 (QG303_05190) 1127852..1128298 - 447 WP_281120885.1 DUF2442 domain-containing protein -
QG303_RS05195 (QG303_05195) 1128592..1129032 + 441 WP_056790556.1 type II 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10769.37 Da        Isoelectric Point: 9.5056

>T279207 WP_281121480.1 NZ_CP123909:1123555-1123833 [Pseudomonas atacamensis]
MIKSFQHKGLRGFYEIGTTRGIRADHAKRLSRMLQFMDRATLPGDLDLPGWRLHPLKGELSEYWSLSVSGNWRVIFRFVG
SDIELVDYLDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10525.13 Da        Isoelectric Point: 6.6962

>AT279207 WP_016773085.1 NZ_CP123909:1123848-1124135 [Pseudomonas atacamensis]
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References