Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2304079..2304578 Replicon chromosome
Accession NZ_CP123853
Organism Staphylococcus aureus strain FDA209P

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NUG19_RS11275 Protein ID WP_000074044.1
Coordinates 2304336..2304578 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NUG19_RS11270 Protein ID WP_000587618.1
Coordinates 2304079..2304336 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG19_RS11250 (2299152) 2299152..2300345 + 1194 WP_000675411.1 MFS transporter -
NUG19_RS11255 (2300576) 2300576..2301325 - 750 WP_000072459.1 CPBP family lipoprotein N-acylation protein LnsB -
NUG19_RS11260 (2301520) 2301520..2303097 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NUG19_RS11265 (2303265) 2303265..2303720 - 456 WP_000732082.1 DUF1307 domain-containing protein -
NUG19_RS11270 (2304079) 2304079..2304336 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NUG19_RS11275 (2304336) 2304336..2304578 + 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
NUG19_RS11280 (2304935) 2304935..2306011 + 1077 WP_042727737.1 M42 family metallopeptidase -
NUG19_RS11285 (2306259) 2306259..2306921 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
NUG19_RS11290 (2306914) 2306914..2307690 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NUG19_RS11295 (2308086) 2308086..2309273 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T279185 WP_000074044.1 NZ_CP123853:2304336-2304578 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT279185 WP_000587618.1 NZ_CP123853:2304079-2304336 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References