Detailed information of TA system TA279181

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19379..19686
• Replicon: chromosome
• Accession: NZ_CP123853
• Organism: Staphylococcus aureus strain FDA209P

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NUG19_RS00100
• Protein ID: WP_072353918.1
• Coordinates: 19379..19555 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19547..19686 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NUG19_RS00080 (14546)	14546..18328	+	3783	WP_042727565.1	phage tail spike protein	-
NUG19_RS00085 (18321)	18321..18473	+	153	WP_001000058.1	hypothetical protein	-
NUG19_RS00090 (18519)	18519..18806	+	288	WP_001262620.1	hypothetical protein	-
NUG19_RS00095 (18862)	18862..19236	+	375	WP_000340977.1	hypothetical protein	-
NUG19_RS00100 (19379)	19379..19555	+	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (19547)	19547..19686	-	140	NuclAT_0	-	Antitoxin
- (19547)	19547..19686	-	140	NuclAT_0	-	Antitoxin
- (19547)	19547..19686	-	140	NuclAT_0	-	Antitoxin
- (19547)	19547..19686	-	140	NuclAT_0	-	Antitoxin
NUG19_RS00105 (19608)	19608..19715	-	108	WP_001791821.1	hypothetical protein	-
NUG19_RS00110 (19767)	19767..20021	+	255	WP_000611512.1	phage holin	-
NUG19_RS00115 (20033)	20033..20788	+	756	WP_000861038.1	CHAP domain-containing protein	-
NUG19_RS00120 (20979)	20979..21470	+	492	WP_000920041.1	staphylokinase	-
NUG19_RS00125 (22122)	22122..22457	+	336	Protein_24	SH3 domain-containing protein	-
NUG19_RS00130 (22967)	22967..23317	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
NUG19_RS00135 (23370)	23370..23630	-	261	WP_001791826.1	hypothetical protein	-
NUG19_RS00140 (23941)	23941..24120	-	180	WP_000669789.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	52..23317	23265

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T279181 WP_072353918.1 NZ_CP123853:19379-19555 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT279181 NZ_CP123853:c19686-19547 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin