Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2362501..2363018 Replicon chromosome
Accession NZ_CP123852
Organism Staphylococcus aureus strain 5812R

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NRK31_RS11555 Protein ID WP_000113262.1
Coordinates 2362752..2363018 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NRK31_RS11550 Protein ID WP_000584499.1
Coordinates 2362501..2362752 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK31_RS11525 (2358345) 2358345..2359664 + 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
NRK31_RS11530 (2359743) 2359743..2360993 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
NRK31_RS11535 (2361248) 2361248..2361610 + 363 WP_000819843.1 DUF4467 domain-containing protein -
NRK31_RS11540 (2361629) 2361629..2362228 + 600 WP_000162813.1 DsbA family protein -
NRK31_RS11545 (2362235) 2362235..2362336 + 102 WP_031774922.1 hypothetical protein -
NRK31_RS11550 (2362501) 2362501..2362752 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NRK31_RS11555 (2362752) 2362752..2363018 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NRK31_RS11560 (2363053) 2363053..2363124 + 72 Protein_2243 hypothetical protein -
NRK31_RS11565 (2363313) 2363313..2364866 + 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NRK31_RS11570 (2365052) 2365052..2365519 + 468 WP_000153344.1 SRPBCC domain-containing protein -
NRK31_RS11575 (2365606) 2365606..2365788 + 183 WP_000079142.1 hypothetical protein -
NRK31_RS11580 (2366005) 2366005..2366829 + 825 WP_000572040.1 formate/nitrite transporter family protein -
NRK31_RS11585 (2367063) 2367063..2367599 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2358345..2359664 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T279176 WP_000113262.1 NZ_CP123852:2362752-2363018 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT279176 WP_000584499.1 NZ_CP123852:2362501-2362752 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References