Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2304078..2304577 Replicon chromosome
Accession NZ_CP123852
Organism Staphylococcus aureus strain 5812R

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NRK31_RS11275 Protein ID WP_000074044.1
Coordinates 2304335..2304577 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NRK31_RS11270 Protein ID WP_000587618.1
Coordinates 2304078..2304335 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK31_RS11250 (2299151) 2299151..2300344 + 1194 WP_000675411.1 MFS transporter -
NRK31_RS11255 (2300575) 2300575..2301324 - 750 WP_000072459.1 CPBP family lipoprotein N-acylation protein LnsB -
NRK31_RS11260 (2301519) 2301519..2303096 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NRK31_RS11265 (2303264) 2303264..2303719 - 456 WP_000732082.1 DUF1307 domain-containing protein -
NRK31_RS11270 (2304078) 2304078..2304335 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NRK31_RS11275 (2304335) 2304335..2304577 + 243 WP_000074044.1 Txe/YoeB family addiction module toxin Toxin
NRK31_RS11280 (2304934) 2304934..2306010 + 1077 WP_042727737.1 M42 family metallopeptidase -
NRK31_RS11285 (2306258) 2306258..2306920 + 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
NRK31_RS11290 (2306913) 2306913..2307689 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NRK31_RS11295 (2308085) 2308085..2309272 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9649.18 Da        Isoelectric Point: 10.1469

>T279174 WP_000074044.1 NZ_CP123852:2304335-2304577 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Download         Length: 243 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT279174 WP_000587618.1 NZ_CP123852:2304078-2304335 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References