279139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 19929..20580 Replicon plasmid pAP8900-2
Accession NZ_CP123767
Organism Acinetobacter pittii strain AP8900

Toxin (Protein)


Gene name higB Uniprot ID N9BC17
Locus tag QFB56_RS19985 Protein ID WP_004967307.1
Coordinates 19929..20285 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB56_RS19990 Protein ID WP_001140620.1
Coordinates 20278..20580 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB56_RS19955 (QFB56_19955) 15442..15762 + 321 Protein_12 integrase core domain-containing protein -
QFB56_RS19960 (QFB56_19960) 15897..16712 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
QFB56_RS19965 (QFB56_19965) 16799..17011 + 213 Protein_14 phosphoglucosamine mutase -
QFB56_RS19970 (QFB56_19970) 17061..17993 + 933 WP_086374392.1 IS5 family transposase -
QFB56_RS19975 (QFB56_19975) 18069..18872 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
QFB56_RS19980 (QFB56_19980) 18872..19708 + 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
QFB56_RS19985 (QFB56_19985) 19929..20285 + 357 WP_004967307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB56_RS19990 (QFB56_19990) 20278..20580 + 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
QFB56_RS19995 (QFB56_19995) 20662..20937 - 276 WP_004967304.1 hypothetical protein -
QFB56_RS20000 (QFB56_20000) 21215..21439 - 225 WP_005155986.1 hypothetical protein -
QFB56_RS20005 (QFB56_20005) 21591..21836 + 246 WP_057692601.1 hypothetical protein -
QFB56_RS20010 (QFB56_20010) 22241..22735 + 495 WP_069120323.1 MobC family plasmid mobilization relaxosome protein -
QFB56_RS20015 (QFB56_20015) 22725..25199 + 2475 WP_069120320.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(E) / mph(E) / tet(39) / cmlB1 / sul2 / aph(3'')-Ib / aph(6)-Id - 1..43600 43600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13601.62 Da        Isoelectric Point: 6.4648

>T279139 WP_004967307.1 NZ_CP123767:19929-20285 [Acinetobacter pittii]
MWIVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGSKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT279139 WP_001140620.1 NZ_CP123767:20278-20580 [Acinetobacter pittii]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4TW67

Antitoxin

Source ID Structure

References