279137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 818..1469 Replicon plasmid pAP8900-1
Accession NZ_CP123766
Organism Acinetobacter pittii strain AP8900

Toxin (Protein)


Gene name higB Uniprot ID A0A7H2WXC0
Locus tag QFB56_RS19325 Protein ID WP_006581604.1
Coordinates 1113..1469 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB56_RS19320 Protein ID WP_001140619.1
Coordinates 818..1120 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB56_RS19310 (QFB56_19310) 288..506 + 219 WP_029747731.1 hypothetical protein -
QFB56_RS19315 (QFB56_19315) 616..825 - 210 WP_000069471.1 hypothetical protein -
QFB56_RS19320 (QFB56_19320) 818..1120 - 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
QFB56_RS19325 (QFB56_19325) 1113..1469 - 357 WP_006581604.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB56_RS19330 (QFB56_19330) 2090..2962 - 873 WP_006581603.1 restriction endonuclease -
QFB56_RS19335 (QFB56_19335) 3166..3447 - 282 WP_000985610.1 putative addiction module antidote protein -
QFB56_RS19340 (QFB56_19340) 3448..3750 - 303 WP_000286963.1 type II toxin-antitoxin system RelE/ParE family toxin -
QFB56_RS19345 (QFB56_19345) 3942..4334 + 393 WP_228713465.1 hypothetical protein -
QFB56_RS19350 (QFB56_19350) 4346..5278 - 933 WP_002048759.1 IS5 family transposase -
QFB56_RS19355 (QFB56_19355) 5332..5811 + 480 Protein_9 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 - 1..86394 86394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13462.38 Da        Isoelectric Point: 7.1642

>T279137 WP_006581604.1 NZ_CP123766:c1469-1113 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT279137 WP_001140619.1 NZ_CP123766:c1120-818 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H2WXC0

Antitoxin

Source ID Structure

References