Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 495650..496182 Replicon chromosome
Accession NZ_CP123735
Organism Lactobacillus kefiranofaciens strain ZW18

Toxin (Protein)


Gene name yoeB Uniprot ID A0A656YA18
Locus tag QEJ78_RS02410 Protein ID WP_013854119.1
Coordinates 495913..496182 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A656Y9W5
Locus tag QEJ78_RS02405 Protein ID WP_013854120.1
Coordinates 495650..495916 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEJ78_RS02380 (QEJ78_02385) 491670..492085 + 416 Protein_470 cupin domain-containing protein -
QEJ78_RS02385 (QEJ78_02390) 492095..492412 + 318 WP_025084192.1 carboxymuconolactone decarboxylase family protein -
QEJ78_RS02390 (QEJ78_02395) 492471..493364 + 894 WP_013854124.1 DUF3737 family protein -
QEJ78_RS02395 (QEJ78_02400) 493370..494539 + 1170 WP_013854123.1 MalY/PatB family protein -
QEJ78_RS02400 (QEJ78_02405) 494536..495399 + 864 WP_025084193.1 alpha/beta hydrolase -
QEJ78_RS02405 (QEJ78_02410) 495650..495916 + 267 WP_013854120.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QEJ78_RS02410 (QEJ78_02415) 495913..496182 + 270 WP_013854119.1 Txe/YoeB family addiction module toxin Toxin
QEJ78_RS02415 (QEJ78_02420) 496368..497705 + 1338 WP_025084196.1 MATE family efflux transporter -
QEJ78_RS02420 (QEJ78_02425) 497823..499724 + 1902 WP_013854117.1 heavy metal translocating P-type ATPase -
QEJ78_RS02425 (QEJ78_02430) 499747..499977 + 231 WP_013854116.1 cation transporter -
QEJ78_RS02430 (QEJ78_02435) 499977..500528 + 552 WP_013854115.1 DNA-binding protein -
QEJ78_RS02435 (QEJ78_02440) 500547..501176 + 630 WP_013854114.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-67)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10617.35 Da        Isoelectric Point: 10.4670

>T279129 WP_013854119.1 NZ_CP123735:495913-496182 [Lactobacillus kefiranofaciens]
MILKYHGRIKNSAKPDLKKIKRSNLKDNFQDIIDQLKKDPYKKNQGFEKLEPPILGKYSRRINIKHRVVYTVDDVNKIVS
IYSAWSHYE

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9984.05 Da        Isoelectric Point: 4.4857

>AT279129 WP_013854120.1 NZ_CP123735:495650-495916 [Lactobacillus kefiranofaciens]
MDATIYTPTGARRNLFNLIKQVNKNHTPVNIESTKDKAESAVLISKSDWDAIQETLYLESNGVGEVVRKREKDNSGFTDI
DDINWDEL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656YA18

Antitoxin

Source ID Structure
AlphaFold DB A0A656Y9W5

References