Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4390835..4391481 Replicon chromosome
Accession NZ_CP123642
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name higB Uniprot ID A0A486UPU4
Locus tag QFW99_RS21985 Protein ID WP_032417639.1
Coordinates 4390835..4391182 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag QFW99_RS21990 Protein ID WP_002920557.1
Coordinates 4391182..4391481 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS21975 (4386761) 4386761..4388194 + 1434 WP_002920564.1 glycogen synthase GlgA -
QFW99_RS21980 (4388212) 4388212..4390659 + 2448 WP_002920561.1 glycogen phosphorylase -
QFW99_RS21985 (4390835) 4390835..4391182 + 348 WP_032417639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFW99_RS21990 (4391182) 4391182..4391481 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
QFW99_RS21995 (4391544) 4391544..4393052 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
QFW99_RS22000 (4393257) 4393257..4393586 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
QFW99_RS22005 (4393637) 4393637..4394467 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
QFW99_RS22010 (4394517) 4394517..4395275 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13527.52 Da        Isoelectric Point: 5.6802

>T279108 WP_032417639.1 NZ_CP123642:4390835-4391182 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKELITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT279108 WP_002920557.1 NZ_CP123642:4391182-4391481 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486UPU4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References