Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1318465..1319059 Replicon chromosome
Accession NC_018013
Organism Aequorivita sublithincola DSM 14238

Toxin (Protein)


Gene name higB Uniprot ID I3YUQ9
Locus tag AEQSU_RS06100 Protein ID WP_014781985.1
Coordinates 1318465..1318746 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AEQSU_RS06105 Protein ID WP_014781986.1
Coordinates 1318757..1319059 (+) Length 101 a.a.

Genomic Context

AEQSU_RS06075AEQSU_RS06100AEQSU_RS06105AEQSU_RS06110AEQSU_RS06120AEQSU_RS06080AEQSU_RS06085AEQSU_RS06090AEQSU_RS06095AEQSU_RS06125AEQSU_RS06130AEQSU_RS06135
Location: 1314325..1315317 (993 bp)
Type: Others
Protein ID: WP_014781980.1
Location: 1318465..1318746 (282 bp)
Type: Toxin
Protein ID: WP_014781985.1
Location: 1318757..1319059 (303 bp)
Type: Antitoxin
Protein ID: WP_014781986.1
Location: 1319069..1319425 (357 bp)
Type: Others
Protein ID: WP_014781987.1
Location: 1319610..1320050 (441 bp)
Type: Others
Protein ID: WP_042491705.1
Location: 1315412..1315663 (252 bp)
Type: Others
Protein ID: WP_014781981.1
Location: 1315669..1316115 (447 bp)
Type: Others
Protein ID: WP_014781982.1
Location: 1316117..1316494 (378 bp)
Type: Others
Protein ID: WP_014781983.1
Location: 1316662..1318341 (1680 bp)
Type: Others
Protein ID: WP_014781984.1
Location: 1320069..1320782 (714 bp)
Type: Others
Protein ID: WP_042491707.1
Location: 1320829..1321506 (678 bp)
Type: Others
Protein ID: WP_014781990.1
Location: 1321519..1323726 (2208 bp)
Type: Others
Protein ID: WP_014781991.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AEQSU_RS060751314325..1315317+993WP_014781980.1SPFH domain-containing protein-
AEQSU_RS060801315412..1315663-252WP_014781981.1hypothetical protein-
AEQSU_RS060851315669..1316115-447WP_014781982.1hypothetical protein-
AEQSU_RS060901316117..1316494-378WP_014781983.1YtxH domain-containing protein-
AEQSU_RS060951316662..1318341-1680WP_014781984.1glutamine--tRNA ligase/YqeY domain fusion protein-
AEQSU_RS061001318465..1318746+282WP_014781985.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AEQSU_RS061051318757..1319059+303WP_014781986.1HigA family addiction module antidote proteinAntitoxin
AEQSU_RS061101319069..1319425+357WP_014781987.1dihydroneopterin aldolase-
AEQSU_RS061201319610..1320050+441WP_042491705.1hypothetical protein-
AEQSU_RS061251320069..1320782-714WP_042491707.1LysE family transporter-
AEQSU_RS061301320829..1321506-678WP_014781990.1DUF2807 domain-containing protein-
AEQSU_RS061351321519..1323726-2208WP_014781991.1ribonuclease R-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11065.85 Da        Isoelectric Point: 11.0790

>T27909 WP_014781985.1 NC_018013:1318465-1318746 [Aequorivita sublithincola DSM 14238]
MILSFGSKETKQIWNGNRVKKIPIEIQNTGRRKLRMLNNSQNINDLRIPPSNRLEKLIGKLNDFYSIRINKKWRIVFIWE
NGNASQVEIIDYH

Download         Length: 282 bp

>T27909 NC_018013:1318465-1318746 [Aequorivita sublithincola DSM 14238]
ATGATATTATCCTTTGGTTCAAAAGAAACAAAGCAGATTTGGAACGGAAATCGTGTTAAAAAAATCCCTATTGAAATTCA
AAATACAGGTCGGAGAAAATTGAGAATGCTAAACAACTCTCAAAATATTAATGATTTAAGAATTCCACCATCAAACAGAC
TTGAAAAACTTATTGGAAAACTAAATGATTTTTACAGTATTAGAATAAACAAAAAATGGCGCATCGTTTTTATTTGGGAA
AATGGAAATGCAAGCCAAGTAGAAATAATTGATTATCATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11598.26 Da        Isoelectric Point: 5.9140

>AT27909 WP_014781986.1 NC_018013:1318757-1319059 [Aequorivita sublithincola DSM 14238]
MEKLGNIHPGEILNLEFLEPLEISAYRLSKDLNIPQTRISEIIKGNRRITADTALRLSKYFGNSAKFWLGIQVDFDIEQE
KENKEKEFNEIKRCADKSVT

Download         Length: 303 bp

>AT27909 NC_018013:1318757-1319059 [Aequorivita sublithincola DSM 14238]
ATGGAGAAATTAGGAAACATCCATCCAGGAGAAATATTGAATTTAGAGTTTCTTGAGCCTCTTGAGATTTCAGCATACAG
GCTTTCAAAAGATTTGAATATCCCTCAAACTAGAATTTCAGAAATAATAAAAGGAAATCGTAGAATTACCGCTGATACAG
CGCTACGGCTTAGTAAATATTTTGGTAATTCTGCAAAATTTTGGCTCGGAATACAAGTTGATTTTGACATTGAACAAGAA
AAAGAAAATAAGGAAAAAGAGTTTAACGAAATAAAAAGATGTGCAGATAAATCTGTGACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI3YUQ9

Antitoxin

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Source
ID
Structure
No matching records found

References