Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1524804..1525464 Replicon chromosome
Accession NZ_CP123607
Organism Serratia marcescens strain RMCH-M16-N

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QFB85_RS07155 Protein ID WP_031300708.1
Coordinates 1524804..1525157 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB85_RS07160 Protein ID WP_280631408.1
Coordinates 1525162..1525464 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB85_RS07135 (QFB85_07135) 1520893..1521258 + 366 WP_004935528.1 diacylglycerol kinase -
QFB85_RS07140 (QFB85_07140) 1521363..1522262 + 900 WP_280631406.1 LysR family transcriptional regulator -
QFB85_RS07145 (QFB85_07145) 1522237..1523043 - 807 WP_280631407.1 substrate-binding domain-containing protein -
QFB85_RS07150 (QFB85_07150) 1523070..1524365 - 1296 WP_004935508.1 MFS transporter -
QFB85_RS07155 (QFB85_07155) 1524804..1525157 + 354 WP_031300708.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB85_RS07160 (QFB85_07160) 1525162..1525464 + 303 WP_280631408.1 XRE family transcriptional regulator Antitoxin
QFB85_RS07165 (QFB85_07165) 1525587..1526495 - 909 WP_004935498.1 LysR family transcriptional regulator -
QFB85_RS07170 (QFB85_07170) 1526634..1527554 + 921 WP_031300707.1 alpha/beta hydrolase -
QFB85_RS07175 (QFB85_07175) 1527554..1528489 + 936 WP_280631410.1 alpha/beta hydrolase -
QFB85_RS07180 (QFB85_07180) 1528506..1529141 + 636 WP_004935489.1 SDR family oxidoreductase -
QFB85_RS07185 (QFB85_07185) 1529184..1529912 + 729 WP_280631411.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1506095..1532659 26564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13609.61 Da        Isoelectric Point: 9.0493

>T279084 WP_031300708.1 NZ_CP123607:1524804-1525157 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11171.02 Da        Isoelectric Point: 5.1992

>AT279084 WP_280631408.1 NZ_CP123607:1525162-1525464 [Serratia marcescens]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAV
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References