Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 784381..785033 Replicon chromosome
Accession NZ_CP123607
Organism Serratia marcescens strain RMCH-M16-N

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QFB85_RS03685 Protein ID WP_280631246.1
Coordinates 784689..785033 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB85_RS03680 Protein ID WP_280631245.1
Coordinates 784381..784683 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB85_RS03655 (QFB85_03655) 779383..780030 - 648 WP_004931818.1 DsbA family protein -
QFB85_RS03660 (QFB85_03660) 780105..780989 - 885 WP_280631242.1 MBL fold metallo-hydrolase -
QFB85_RS03665 (QFB85_03665) 781098..782006 + 909 WP_015378928.1 LysR family transcriptional regulator -
QFB85_RS03670 (QFB85_03670) 782034..782957 - 924 WP_280631243.1 LysR family transcriptional regulator -
QFB85_RS03675 (QFB85_03675) 783091..784353 + 1263 WP_280631244.1 diaminopimelate decarboxylase -
QFB85_RS03680 (QFB85_03680) 784381..784683 - 303 WP_280631245.1 XRE family transcriptional regulator Antitoxin
QFB85_RS03685 (QFB85_03685) 784689..785033 - 345 WP_280631246.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB85_RS03690 (QFB85_03690) 785191..786210 - 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
QFB85_RS03695 (QFB85_03695) 786431..788689 + 2259 WP_280631247.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13341.36 Da        Isoelectric Point: 10.6087

>T279082 WP_280631246.1 NZ_CP123607:c785033-784689 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRGFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11064.93 Da        Isoelectric Point: 10.1998

>AT279082 WP_280631245.1 NZ_CP123607:c784683-784381 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTP

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References