Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1212710..1213312 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name higB Uniprot ID A0A5E1AN02
Locus tag QFB83_RS05915 Protein ID WP_013099360.1
Coordinates 1213001..1213312 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB83_RS05910 Protein ID WP_013099359.1
Coordinates 1212710..1213000 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS05895 (QFB83_05895) 1210207..1211109 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
QFB83_RS05900 (QFB83_05900) 1211106..1211741 + 636 WP_013099357.1 formate dehydrogenase cytochrome b556 subunit -
QFB83_RS05905 (QFB83_05905) 1211738..1212667 + 930 WP_280597093.1 formate dehydrogenase accessory protein FdhE -
QFB83_RS05910 (QFB83_05910) 1212710..1213000 - 291 WP_013099359.1 helix-turn-helix domain-containing protein Antitoxin
QFB83_RS05915 (QFB83_05915) 1213001..1213312 - 312 WP_013099360.1 hypothetical protein Toxin
QFB83_RS05920 (QFB83_05920) 1213542..1214459 + 918 WP_280597096.1 alpha/beta hydrolase -
QFB83_RS05925 (QFB83_05925) 1214472..1215413 - 942 WP_057072637.1 fatty acid biosynthesis protein FabY -
QFB83_RS05930 (QFB83_05930) 1215458..1215895 - 438 WP_013099363.1 D-aminoacyl-tRNA deacylase -
QFB83_RS05935 (QFB83_05935) 1215892..1216773 - 882 WP_013099364.1 virulence factor BrkB family protein -
QFB83_RS05940 (QFB83_05940) 1216767..1217366 - 600 WP_013099365.1 glucose-1-phosphatase -
QFB83_RS05945 (QFB83_05945) 1217486..1218286 - 801 WP_013099366.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12210.18 Da        Isoelectric Point: 9.7550

>T279065 WP_013099360.1 NZ_CP123598:c1213312-1213001 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLATQPDYGDLIQNTGGLRKIRWLSGGRGKRGGVRVIYFHRTHEFEIRLLLIY
RKGIKDDLSAREKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10623.13 Da        Isoelectric Point: 10.4747

>AT279065 WP_013099359.1 NZ_CP123598:c1213000-1212710 [Enterobacter cloacae]
MDKALFERLTQSIAQMDDIVGGKREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVISALSD

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AN02

Antitoxin

Source ID Structure

References