Detailed information of TA system TA027906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1829981..1830587
• Replicon: chromosome
• Accession: NC_018012
• Organism: Thiocystis violascens DSM 198

Toxin (Protein)

• Gene name: higB
• Uniprot ID: I3Y9J6
• Locus tag: THIVI_RS08170
• Protein ID: WP_014778125.1
• Coordinates: 1829981..1830313 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: THIVI_RS08175
• Protein ID: WP_014778126.1
• Coordinates: 1830300..1830587 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIVI_RS08155	1827138..1827674	+	537	WP_014778122.1	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	-
THIVI_RS08160	1827962..1828846	+	885	WP_014778123.1	hypothetical protein	-
THIVI_RS24625	1828954..1829670	+	717	WP_014778124.1	hypothetical protein	-
THIVI_RS08170	1829981..1830313	+	333	WP_014778125.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
THIVI_RS08175	1830300..1830587	+	288	WP_014778126.1	helix-turn-helix domain-containing protein	Antitoxin
THIVI_RS08180	1831083..1831697	+	615	WP_014778127.1	LysE family translocator	-
THIVI_RS08185	1831723..1831998	+	276	WP_014778128.1	helix-turn-helix domain-containing protein	-
THIVI_RS23535	1832049..1832252	+	204	WP_014778129.1	type II toxin-antitoxin system HicA family toxin	-
THIVI_RS23540	1832249..1832470	+	222	WP_014778130.1	hypothetical protein	-
THIVI_RS08195	1832582..1833193	-	612	WP_157174408.1	epoxyqueuosine reductase QueH	-
THIVI_RS08200	1833215..1834609	-	1395	WP_157174409.1	cobyrinate a,c-diamide synthase	-
THIVI_RS08205	1834625..1835056	+	432	WP_014778133.1	cobalamin biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-91)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12502.62 Da
• Isoelectric Point: 9.8440

>T27906 WP_014778125.1 NC_018012:1829981-1830313 [Thiocystis violascens DSM 198]
MDYSIEYYSDAVAEEILALPDTLAARYLVLARRIMAVGPNLGPPHTDAFGDGLFELRLKGQEGIARLFFCALVGRRVMIL
HSFIKKTQKTPQREIEIARKRMKEVRHANS

Nucleotide

• Length: 333 bp

>T27906 NC_018012:1829981-1830313 [Thiocystis violascens DSM 198]
ATGGACTACTCCATTGAGTACTACAGTGACGCCGTGGCCGAGGAGATCCTCGCGCTCCCGGACACGCTCGCCGCAAGATA
CCTCGTACTCGCAAGAAGAATAATGGCTGTTGGTCCGAATCTCGGGCCTCCGCACACGGACGCCTTCGGCGATGGCCTGT
TCGAACTACGGCTGAAGGGTCAGGAGGGAATTGCCAGACTCTTCTTCTGCGCGCTCGTTGGCCGCAGGGTGATGATTTTG
CACTCCTTCATCAAAAAAACCCAGAAAACTCCACAGCGAGAAATTGAGATTGCGCGCAAGCGCATGAAGGAGGTCAGGCA
TGCGAACTCATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10454.11 Da
• Isoelectric Point: 9.9004

>AT27906 WP_014778126.1 NC_018012:1830300-1830587 [Thiocystis violascens DSM 198]
MRTHDEVVSKLMQRPGVCQEVERIEREEGVLLDILLKARQEAGLSQAQVAERMGTQAPAVARLERSLATGKHSPSLATLR
KYAQACGKKLSVQLS

Nucleotide

• Length: 288 bp

>AT27906 NC_018012:1830300-1830587 [Thiocystis violascens DSM 198]
ATGCGAACTCATGACGAAGTTGTTTCCAAGCTGATGCAGCGTCCCGGCGTCTGTCAGGAAGTCGAGCGCATCGAACGAGA
GGAAGGCGTGCTACTTGATATCCTGCTAAAGGCGCGTCAAGAAGCCGGGTTGTCCCAGGCCCAGGTCGCCGAGCGCATGG
GGACTCAAGCCCCAGCGGTTGCACGCCTGGAAAGGTCTCTGGCTACGGGGAAACATTCGCCTTCGCTGGCAACACTACGC
AAGTACGCACAGGCTTGTGGCAAGAAACTCTCAGTTCAGCTCTCGTAG

Structures

Toxin

• AlphaFold DB: I3Y9J6