Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1829981..1830587 Replicon chromosome
Accession NC_018012
Organism Thiocystis violascens DSM 198

Toxin (Protein)


Gene name higB Uniprot ID I3Y9J6
Locus tag THIVI_RS08170 Protein ID WP_014778125.1
Coordinates 1829981..1830313 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag THIVI_RS08175 Protein ID WP_014778126.1
Coordinates 1830300..1830587 (+) Length 96 a.a.

Genomic Context

THIVI_RS08155THIVI_RS08160THIVI_RS24625THIVI_RS08170THIVI_RS08175THIVI_RS08180THIVI_RS08185THIVI_RS23535THIVI_RS23540THIVI_RS08205THIVI_RS08195THIVI_RS08200
Location: 1827138..1827674 (537 bp)
Type: Others
Protein ID: WP_014778122.1
Location: 1827962..1828846 (885 bp)
Type: Others
Protein ID: WP_014778123.1
Location: 1828954..1829670 (717 bp)
Type: Others
Protein ID: WP_014778124.1
Location: 1829981..1830313 (333 bp)
Type: Toxin
Protein ID: WP_014778125.1
Location: 1830300..1830587 (288 bp)
Type: Antitoxin
Protein ID: WP_014778126.1
Location: 1831083..1831697 (615 bp)
Type: Others
Protein ID: WP_014778127.1
Location: 1831723..1831998 (276 bp)
Type: Others
Protein ID: WP_014778128.1
Location: 1832049..1832252 (204 bp)
Type: Others
Protein ID: WP_014778129.1
Location: 1832249..1832470 (222 bp)
Type: Others
Protein ID: WP_014778130.1
Location: 1834625..1835056 (432 bp)
Type: Others
Protein ID: WP_014778133.1
Location: 1832582..1833193 (612 bp)
Type: Others
Protein ID: WP_157174408.1
Location: 1833215..1834609 (1395 bp)
Type: Others
Protein ID: WP_157174409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
THIVI_RS081551827138..1827674+537WP_014778122.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase-
THIVI_RS081601827962..1828846+885WP_014778123.1hypothetical protein-
THIVI_RS246251828954..1829670+717WP_014778124.1hypothetical protein-
THIVI_RS081701829981..1830313+333WP_014778125.1type II toxin-antitoxin system RelE/ParE family toxinToxin
THIVI_RS081751830300..1830587+288WP_014778126.1helix-turn-helix domain-containing proteinAntitoxin
THIVI_RS081801831083..1831697+615WP_014778127.1LysE family translocator-
THIVI_RS081851831723..1831998+276WP_014778128.1helix-turn-helix domain-containing protein-
THIVI_RS235351832049..1832252+204WP_014778129.1type II toxin-antitoxin system HicA family toxin-
THIVI_RS235401832249..1832470+222WP_014778130.1hypothetical protein-
THIVI_RS081951832582..1833193-612WP_157174408.1epoxyqueuosine reductase QueH-
THIVI_RS082001833215..1834609-1395WP_157174409.1cobyrinate a,c-diamide synthase-
THIVI_RS082051834625..1835056+432WP_014778133.1cobalamin biosynthesis protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-91)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12502.62 Da        Isoelectric Point: 9.8440

>T27906 WP_014778125.1 NC_018012:1829981-1830313 [Thiocystis violascens DSM 198]
MDYSIEYYSDAVAEEILALPDTLAARYLVLARRIMAVGPNLGPPHTDAFGDGLFELRLKGQEGIARLFFCALVGRRVMIL
HSFIKKTQKTPQREIEIARKRMKEVRHANS

Download         Length: 333 bp

>T27906 NC_018012:1829981-1830313 [Thiocystis violascens DSM 198]
ATGGACTACTCCATTGAGTACTACAGTGACGCCGTGGCCGAGGAGATCCTCGCGCTCCCGGACACGCTCGCCGCAAGATA
CCTCGTACTCGCAAGAAGAATAATGGCTGTTGGTCCGAATCTCGGGCCTCCGCACACGGACGCCTTCGGCGATGGCCTGT
TCGAACTACGGCTGAAGGGTCAGGAGGGAATTGCCAGACTCTTCTTCTGCGCGCTCGTTGGCCGCAGGGTGATGATTTTG
CACTCCTTCATCAAAAAAACCCAGAAAACTCCACAGCGAGAAATTGAGATTGCGCGCAAGCGCATGAAGGAGGTCAGGCA
TGCGAACTCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10454.11 Da        Isoelectric Point: 9.9004

>AT27906 WP_014778126.1 NC_018012:1830300-1830587 [Thiocystis violascens DSM 198]
MRTHDEVVSKLMQRPGVCQEVERIEREEGVLLDILLKARQEAGLSQAQVAERMGTQAPAVARLERSLATGKHSPSLATLR
KYAQACGKKLSVQLS

Download         Length: 288 bp

>AT27906 NC_018012:1830300-1830587 [Thiocystis violascens DSM 198]
ATGCGAACTCATGACGAAGTTGTTTCCAAGCTGATGCAGCGTCCCGGCGTCTGTCAGGAAGTCGAGCGCATCGAACGAGA
GGAAGGCGTGCTACTTGATATCCTGCTAAAGGCGCGTCAAGAAGCCGGGTTGTCCCAGGCCCAGGTCGCCGAGCGCATGG
GGACTCAAGCCCCAGCGGTTGCACGCCTGGAAAGGTCTCTGGCTACGGGGAAACATTCGCCTTCGCTGGCAACACTACGC
AAGTACGCACAGGCTTGTGGCAAGAAACTCTCAGTTCAGCTCTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI3Y9J6

Antitoxin

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Source
ID
Structure
No matching records found

References