Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2577426..2578074 Replicon chromosome
Accession NZ_CP123597
Organism Serratia marcescens strain RMCH-M26-N

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QFB82_RS12530 Protein ID WP_280598412.1
Coordinates 2577733..2578074 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag QFB82_RS12525 Protein ID WP_033635213.1
Coordinates 2577426..2577728 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB82_RS12505 (QFB82_12505) 2573053..2573967 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
QFB82_RS12510 (QFB82_12510) 2574091..2575209 - 1119 WP_033632602.1 branched-chain amino acid ABC transporter substrate-binding protein -
QFB82_RS12520 (QFB82_12520) 2575792..2577000 - 1209 WP_280598411.1 aldose 1-epimerase family protein -
QFB82_RS12525 (QFB82_12525) 2577426..2577728 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
QFB82_RS12530 (QFB82_12530) 2577733..2578074 - 342 WP_280598412.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB82_RS12535 (QFB82_12535) 2578513..2579808 + 1296 WP_033632599.1 MFS transporter -
QFB82_RS12540 (QFB82_12540) 2579835..2580641 + 807 WP_261440864.1 substrate-binding domain-containing protein -
QFB82_RS12545 (QFB82_12545) 2580616..2581515 - 900 WP_280598413.1 LysR family transcriptional regulator -
QFB82_RS12550 (QFB82_12550) 2581619..2582104 - 486 WP_228392530.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-101)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13306.34 Da        Isoelectric Point: 9.8278

>T279057 WP_280598412.1 NZ_CP123597:c2578074-2577733 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQRRGEPLRAFFAFDPYRVGM
VLCAGNKKRFYDRMLQIVDREFTNWLNTLNEKE

Download         Length: 342 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT279057 WP_033635213.1 NZ_CP123597:c2577728-2577426 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References