Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 556339..556960 Replicon chromosome
Accession NZ_CP123498
Organism Arsenophonus nasoniae strain aIh

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QE207_RS04515 Protein ID WP_280548710.1
Coordinates 556339..556668 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QE207_RS04520 Protein ID WP_280548712.1
Coordinates 556658..556960 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE207_RS04485 (QE207_04480) 551773..552276 - 504 WP_280629593.1 hypothetical protein -
QE207_RS04490 (QE207_04485) 552312..552833 - 522 WP_280629594.1 hypothetical protein -
QE207_RS04495 (QE207_04490) 553099..553802 - 704 Protein_487 IS6 family transposase -
QE207_RS04500 (QE207_04495) 553882..554352 - 471 WP_280629595.1 hypothetical protein -
QE207_RS04505 (QE207_04500) 554799..555482 + 684 Protein_489 IS6 family transposase -
QE207_RS04510 (QE207_04505) 555491..556213 - 723 WP_280629596.1 conserved phage C-terminal domain-containing protein -
QE207_RS04515 (QE207_04510) 556339..556668 + 330 WP_280548710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QE207_RS04520 (QE207_04515) 556658..556960 + 303 WP_280548712.1 helix-turn-helix transcriptional regulator Antitoxin
QE207_RS04525 (QE207_04520) 557046..557729 - 684 WP_280629597.1 IS6 family transposase -
QE207_RS04530 (QE207_04525) 558074..558352 - 279 WP_280629598.1 helix-turn-helix transcriptional regulator -
QE207_RS04535 (QE207_04530) 558650..559582 + 933 WP_280629599.1 Rpn family recombination-promoting nuclease/putative transposase -
QE207_RS04540 (QE207_04535) 559867..560034 + 168 WP_280629600.1 hypothetical protein -
QE207_RS04545 (QE207_04540) 560031..560321 + 291 WP_280629601.1 transcriptional regulator -
QE207_RS04550 (QE207_04545) 561063..561332 + 270 WP_280629602.1 Cox family DNA-binding protein -
QE207_RS04555 (QE207_04550) 561320..561475 + 156 WP_280629603.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 520832..595437 74605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-92)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12787.95 Da        Isoelectric Point: 9.9501

>T278999 WP_280548710.1 NZ_CP123498:556339-556668 [Arsenophonus nasoniae]
MKYTIEYYSEEVEKDILSLPDTIQARYIRYTEKMRIYGANLGEPHTSSFGDGLFELRLKGCEGIGRVFYCTLIGKRIVML
HSFIKKTNKTPIKERQKAEKRLKEVKYGK

Download         Length: 330 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10984.87 Da        Isoelectric Point: 10.5338

>AT278999 WP_280548712.1 NZ_CP123498:556658-556960 [Arsenophonus nasoniae]
MANKRTMMTHDELVEKMLSNPKVKAEYDAIAEEFALLDEILAARKNAGLTQEQLAKRMGTKATAITRMESNLASGVSGPS
FSTLKKLAKATGKKLQIRFV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References