Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 131563..132290 Replicon plasmid pYUSHP16-1
Accession NZ_CP123431
Organism Klebsiella pneumoniae strain SH22PE16

Toxin (Protein)


Gene name higB Uniprot ID A0A7W3D9W1
Locus tag QEZ34_RS25470 Protein ID WP_011251285.1
Coordinates 131979..132290 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QEZ34_RS25465 Protein ID WP_011251286.1
Coordinates 131563..131982 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEZ34_RS25450 128554..129249 - 696 WP_064160295.1 molecular chaperone -
QEZ34_RS25455 129308..129877 - 570 WP_064160296.1 fimbrial protein -
QEZ34_RS25460 130424..131392 + 969 WP_016151349.1 IS5 family transposase -
QEZ34_RS25465 131563..131982 - 420 WP_011251286.1 helix-turn-helix domain-containing protein Antitoxin
QEZ34_RS25470 131979..132290 - 312 WP_011251285.1 type II toxin-antitoxin system HigB family toxin Toxin
QEZ34_RS25475 132495..132932 - 438 Protein_134 DDE-type integrase/transposase/recombinase -
QEZ34_RS25480 133046..133384 + 339 WP_023288266.1 transposase -
QEZ34_RS25485 133381..133728 + 348 WP_032430752.1 IS66 family insertion sequence element accessory protein TnpB -
QEZ34_RS25490 133777..135315 + 1539 WP_032430751.1 IS66 family transposase -
QEZ34_RS25495 135355..135534 + 180 Protein_138 IS5/IS1182 family transposase -
QEZ34_RS25500 136079..137059 - 981 WP_048293850.1 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / sul2 pla 1..218903 218903
- inside IScluster/Tn - - 130424..137059 6635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12346.12 Da        Isoelectric Point: 9.7248

>T278987 WP_011251285.1 NZ_CP123431:c132290-131979 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15377.46 Da        Isoelectric Point: 4.4420

>AT278987 WP_011251286.1 NZ_CP123431:c131982-131563 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3D9W1

Antitoxin

Source ID Structure

References