Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 85210..85742 Replicon plasmid p15758B_210
Accession NZ_CP123369
Organism Providencia rettgeri strain PreM15758

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag KOL64_RS20445 Protein ID WP_140172931.1
Coordinates 85467..85742 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag KOL64_RS20440 Protein ID WP_283656904.1
Coordinates 85210..85473 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL64_RS20425 (KOL64_20690) 80949..81122 - 174 WP_180359558.1 hypothetical protein -
KOL64_RS20430 (KOL64_20695) 81205..84231 - 3027 WP_042849110.1 Tn3 family transposase -
KOL64_RS20435 (KOL64_20700) 84408..85037 + 630 WP_180359559.1 recombinase family protein -
KOL64_RS20440 (KOL64_20705) 85210..85473 + 264 WP_283656904.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KOL64_RS20445 (KOL64_20710) 85467..85742 + 276 WP_140172931.1 type II toxin-antitoxin system YafQ family toxin Toxin
KOL64_RS20450 (KOL64_20715) 85843..85953 - 111 WP_257468673.1 arylsulfatase -
KOL64_RS20455 (KOL64_20720) 86186..87399 + 1214 WP_283656903.1 IS3 family transposase -
KOL64_RS20460 (KOL64_20725) 87672..87827 - 156 WP_283658130.1 hypothetical protein -
KOL64_RS20465 (KOL64_20730) 88779..89294 + 516 WP_125894902.1 hypothetical protein -
KOL64_RS20470 (KOL64_20735) 89378..89545 + 168 WP_282553685.1 hypothetical protein -
KOL64_RS20475 (KOL64_20740) 89530..89808 + 279 WP_180359560.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-1 / aph(3')-VI / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / aph(3')-Ia / qnrD1 groEL 1..209862 209862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10608.25 Da        Isoelectric Point: 9.9690

>T278966 WP_140172931.1 NZ_CP123369:85467-85742 [Providencia rettgeri]
MLTPIRSSAFKADVKRQKKRGKDLNKLKVLIELLIKEEQIPADYVDHPLTGNWRGYRDAHIEGDWLLIYKITGQELKLAR
TGSHQDIFSQY

Download         Length: 276 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9357.84 Da        Isoelectric Point: 5.0939

>AT278966 WP_283656904.1 NZ_CP123369:85210-85473 [Providencia rettgeri]
MISDTTVKARISQDVKERAVSALAKMGLNTSDLIRMVMIRVADEGKLPFDIKTPNVVTKEAIEELEKGNGKAFSSTNALF
DDLGIC

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References