Detailed information of TA system TA278949

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1397783..1398008
• Replicon: chromosome
• Accession: NZ_CP123365
• Organism: Shigella flexneri strain MMGSG_23

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: PFB08_RS07095
• Protein ID: WP_000813254.1
• Coordinates: 1397853..1398008 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1397783..1397841 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PFB08_RS07055	1393781..1393950	+	170	Protein_1376	hypothetical protein	-
PFB08_RS07060	1394096..1394842	+	747	WP_000789015.1	ATP-binding protein	-
PFB08_RS07065	1394857..1395279	+	423	WP_001118168.1	DUF977 family protein	-
PFB08_RS07070	1395337..1395693	+	357	WP_005048249.1	hypothetical protein	-
PFB08_RS07075	1395786..1396004	+	219	WP_000256998.1	DUF4014 family protein	-
PFB08_RS07080	1396006..1396371	+	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
PFB08_RS07085	1396368..1397033	+	666	WP_000208062.1	hypothetical protein	-
PFB08_RS07090	1397033..1397398	+	366	WP_000610655.1	DUF551 domain-containing protein	-
-	1397783..1397841	-	59	-	-	Antitoxin
PFB08_RS07095	1397853..1398008	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
PFB08_RS07105	1399345..1399944	+	600	WP_000940329.1	DUF1367 family protein	-
PFB08_RS07110	1399944..1400234	+	291	WP_000228038.1	DUF1364 domain-containing protein	-
PFB08_RS07115	1400231..1400785	+	555	WP_000640143.1	DUF1133 family protein	-
PFB08_RS07120	1400938..1401111	+	174	WP_000504450.1	hypothetical protein	-
PFB08_RS07125	1401173..1402329	+	1157	WP_094105050.1	IS3-like element IS600 family transposase	-
PFB08_RS07130	1402357..1402725	+	369	WP_011069357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	1385770..1444799	59029

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T278949 WP_000813254.1 NZ_CP123365:1397853-1398008 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT278949 NZ_CP123365:c1397841-1397783 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin