Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 416621..417239 Replicon chromosome
Accession NZ_CP123365
Organism Shigella flexneri strain MMGSG_23

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PFB08_RS02050 Protein ID WP_001291435.1
Coordinates 416621..416839 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag PFB08_RS02055 Protein ID WP_000344797.1
Coordinates 416865..417239 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFB08_RS02020 (412513) 412513..412824 - 312 WP_000409911.1 MGMT family protein -
PFB08_RS02030 (413203) 413203..413556 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PFB08_RS02035 (413598) 413598..415148 - 1551 WP_005098218.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PFB08_RS02040 (415312) 415312..415782 - 471 WP_000136192.1 YlaC family protein -
PFB08_RS02045 (415898) 415898..416449 - 552 Protein_398 maltose O-acetyltransferase -
PFB08_RS02050 (416621) 416621..416839 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PFB08_RS02055 (416865) 416865..417239 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
PFB08_RS02060 (417785) 417785..420934 - 3150 WP_001132518.1 efflux RND transporter permease AcrB -
PFB08_RS02065 (420957) 420957..422150 - 1194 WP_011069267.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 411155..412483 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278944 WP_001291435.1 NZ_CP123365:c416839-416621 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT278944 WP_000344797.1 NZ_CP123365:c417239-416865 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References