278943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 379439..380283 Replicon chromosome
Accession NZ_CP123365
Organism Shigella flexneri strain MMGSG_23

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag PFB08_RS01855 Protein ID WP_014532172.1
Coordinates 379439..379900 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag PFB08_RS01860 Protein ID WP_005053053.1
Coordinates 379972..380283 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFB08_RS01840 (374607) 374607..376337 - 1731 WP_000645013.1 hypothetical protein -
PFB08_RS01845 (376390) 376390..378543 - 2154 WP_005060811.1 SEL1-like repeat protein -
PFB08_RS01850 (378694) 378694..379391 + 698 WP_223368647.1 IS1 family transposase -
PFB08_RS01855 (379439) 379439..379900 - 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
PFB08_RS01860 (379972) 379972..380283 - 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
PFB08_RS01865 (380467) 380467..381357 - 891 WP_000971346.1 heme o synthase -
PFB08_RS01870 (381369) 381369..381698 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PFB08_RS01875 (381698) 381698..382312 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PFB08_RS01880 (382302) 382302..384293 - 1992 Protein_366 cytochrome o ubiquinol oxidase subunit I -
PFB08_RS01885 (384315) 384315..384812 - 498 Protein_367 COX aromatic rich motif-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 378888..379391 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T278943 WP_014532172.1 NZ_CP123365:c379900-379439 [Shigella flexneri]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT278943 WP_005053053.1 NZ_CP123365:c380283-379972 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References