Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 271347..271983 Replicon chromosome
Accession NZ_CP123352
Organism Agrobacterium pusense strain GV2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QE155_RS14470 Protein ID WP_280170931.1
Coordinates 271702..271983 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag QE155_RS14465 Protein ID WP_004444714.1
Coordinates 271347..271646 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE155_RS14440 266535..267263 - 729 WP_280170927.1 ABC transporter ATP-binding protein -
QE155_RS14445 267260..268168 - 909 WP_035208323.1 branched-chain amino acid ABC transporter permease -
QE155_RS14450 268165..269037 - 873 WP_280170928.1 branched-chain amino acid ABC transporter permease -
QE155_RS14455 269108..270322 - 1215 WP_280170929.1 amino acid ABC transporter substrate-binding protein -
QE155_RS14460 270455..271327 + 873 WP_280170930.1 helix-turn-helix transcriptional regulator -
QE155_RS14465 271347..271646 - 300 WP_004444714.1 HigA family addiction module antitoxin Antitoxin
QE155_RS14470 271702..271983 - 282 WP_280170931.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QE155_RS14475 272061..272867 - 807 WP_280170932.1 ABC transporter ATP-binding protein -
QE155_RS14480 272864..273898 - 1035 WP_280170933.1 iron chelate uptake ABC transporter family permease subunit -
QE155_RS14485 273901..274944 - 1044 WP_280170934.1 iron ABC transporter permease -
QE155_RS14490 274941..275948 - 1008 WP_280170935.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10637.07 Da        Isoelectric Point: 9.0298

>T278938 WP_280170931.1 NZ_CP123352:c271983-271702 [Agrobacterium pusense]
MIRSFKNKLTASIDDGSVKKGFPSDMLRRAQQLLTILDAANTVEDLRSPPGNRLEKLSGDREGQYSIRINKQWRICFVWT
QAGPENVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11060.86 Da        Isoelectric Point: 8.5148

>AT278938 WP_004444714.1 NZ_CP123352:c271646-271347 [Agrobacterium pusense]
MTISKSPPIHPGEILRELYLEPLGMSAYALARHLNVPRTRIERIAGEKLGITADTALRLAKFFKTTPEYWLNLQNAFDIK
AAAARLETDLANIKELEAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References