278912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4517460..4518062 Replicon chromosome
Accession NZ_CP123282
Organism Salmonella sp. SA14318

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag QEN32_RS21495 Protein ID WP_001159632.1
Coordinates 4517751..4518062 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QEN32_RS21490 Protein ID WP_000362050.1
Coordinates 4517460..4517750 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN32_RS21475 (4514953) 4514953..4515855 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
QEN32_RS21480 (4515852) 4515852..4516487 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QEN32_RS21485 (4516484) 4516484..4517413 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
QEN32_RS21490 (4517460) 4517460..4517750 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QEN32_RS21495 (4517751) 4517751..4518062 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QEN32_RS21500 (4518280) 4518280..4519209 + 930 WP_265322369.1 alpha/beta hydrolase -
QEN32_RS21505 (4519295) 4519295..4519606 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
QEN32_RS21510 (4519603) 4519603..4520049 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
QEN32_RS21515 (4520064) 4520064..4521005 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QEN32_RS21520 (4521050) 4521050..4521487 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
QEN32_RS21525 (4521484) 4521484..4522356 - 873 WP_000921423.1 virulence factor BrkB family protein -
QEN32_RS21530 (4522350) 4522350..4522949 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T278912 WP_001159632.1 NZ_CP123282:c4518062-4517751 [Salmonella sp. SA14318]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT278912 WP_000362050.1 NZ_CP123282:c4517750-4517460 [Salmonella sp. SA14318]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References