278888

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3030968..3031570 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag QEN30_RS15215 Protein ID WP_001159630.1
Coordinates 3031259..3031570 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QEN30_RS15210 Protein ID WP_000362050.1
Coordinates 3030968..3031258 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS15195 (3028461) 3028461..3029363 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
QEN30_RS15200 (3029360) 3029360..3029995 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QEN30_RS15205 (3029992) 3029992..3030921 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
QEN30_RS15210 (3030968) 3030968..3031258 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QEN30_RS15215 (3031259) 3031259..3031570 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QEN30_RS15220 (3031788) 3031788..3032717 + 930 WP_001127703.1 alpha/beta hydrolase -
QEN30_RS15225 (3032803) 3032803..3033114 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
QEN30_RS15230 (3033111) 3033111..3033557 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
QEN30_RS15235 (3033572) 3033572..3034513 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QEN30_RS15240 (3034558) 3034558..3034995 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
QEN30_RS15245 (3034992) 3034992..3035864 - 873 WP_000921427.1 virulence factor BrkB family protein -
QEN30_RS15250 (3035858) 3035858..3036457 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T278888 WP_001159630.1 NZ_CP123280:c3031570-3031259 [Salmonella sp. SA17155]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT278888 WP_000362050.1 NZ_CP123280:c3031258-3030968 [Salmonella sp. SA17155]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References