Detailed information of TA system TA278880

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 345070..345295
• Replicon: chromosome
• Accession: NZ_CP123280
• Organism: Salmonella sp. SA17155

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: QEN30_RS01980
• Protein ID: WP_000813254.1
• Coordinates: 345140..345295 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	345070..345128 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QEN30_RS01950	340508..341254	+	747	WP_052929112.1	ATP-binding protein	-
QEN30_RS01955	341277..342038	+	762	WP_139707682.1	DUF1627 domain-containing protein	-
QEN30_RS01960	342054..342476	+	423	WP_050306692.1	DUF977 family protein	-
QEN30_RS01965	342473..342673	+	201	WP_042973267.1	hypothetical protein	-
QEN30_RS01970	342947..343525	+	579	WP_001204666.1	sce7726 family protein	-
QEN30_RS01975	343485..344582	-	1098	WP_042973270.1	beta family protein	-
-	345070..345128	-	59	-	-	Antitoxin
QEN30_RS01980	345140..345295	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
QEN30_RS01985	345571..345783	+	213	WP_052929182.1	hypothetical protein	-
QEN30_RS01990	345855..346454	+	600	WP_052929183.1	DUF1367 family protein	-
QEN30_RS01995	346454..346744	+	291	WP_001533370.1	DUF1364 domain-containing protein	-
QEN30_RS02000	346741..347283	+	543	WP_000640144.1	DUF1133 family protein	-
QEN30_RS02005	347767..348102	+	336	WP_001533367.1	phage holin, lambda family	-
QEN30_RS02010	348106..348582	+	477	WP_001194114.1	glycoside hydrolase family protein	-
QEN30_RS02015	348566..348958	+	393	WP_042043867.1	DUF2570 domain-containing protein	-
QEN30_RS02020	348843..349121	+	279	WP_173671027.1	hypothetical protein	-
QEN30_RS02025	349102..349287	+	186	WP_000113285.1	hypothetical protein	-
QEN30_RS02030	349420..349968	-	549	WP_000762846.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sopE2	325009..405757	80748

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T278880 WP_000813254.1 NZ_CP123280:345140-345295 [Salmonella sp. SA17155]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T278880 NZ_CP123280:345140-345295 [Salmonella sp. SA17155]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT278880 NZ_CP123280:c345128-345070 [Salmonella sp. SA17155]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin