Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4698677..4699279 Replicon chromosome
Accession NZ_CP123266
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag N4686_RS22680 Protein ID WP_000897305.1
Coordinates 4698968..4699279 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4686_RS22675 Protein ID WP_000356397.1
Coordinates 4698677..4698967 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS22650 (4694603) 4694603..4695505 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N4686_RS22655 (4695502) 4695502..4696137 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N4686_RS22660 (4696134) 4696134..4697063 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
N4686_RS22665 (4697393) 4697393..4697635 - 243 WP_001086388.1 protein YiiF -
N4686_RS22670 (4697854) 4697854..4698072 - 219 WP_001295676.1 CopG family transcriptional regulator -
N4686_RS22675 (4698677) 4698677..4698967 - 291 WP_000356397.1 NadS family protein Antitoxin
N4686_RS22680 (4698968) 4698968..4699279 - 312 WP_000897305.1 hypothetical protein Toxin
N4686_RS22685 (4699508) 4699508..4700416 + 909 WP_001162704.1 alpha/beta hydrolase -
N4686_RS22690 (4700480) 4700480..4701421 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N4686_RS22695 (4701466) 4701466..4701903 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N4686_RS22700 (4701900) 4701900..4702772 - 873 WP_000920762.1 virulence factor BrkB family protein -
N4686_RS22705 (4702766) 4702766..4703365 - 600 WP_001295269.1 glucose-1-phosphatase -
N4686_RS22710 (4703464) 4703464..4704249 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278864 WP_000897305.1 NZ_CP123266:c4699279-4698968 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278864 WP_000356397.1 NZ_CP123266:c4698967-4698677 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References