Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3813332..3813873 Replicon chromosome
Accession NZ_CP123266
Organism Escherichia coli strain YZLc23-1

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag N4686_RS18565 Protein ID WP_000615976.1
Coordinates 3813595..3813873 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag N4686_RS18560 Protein ID WP_000729704.1
Coordinates 3813332..3813592 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4686_RS18535 (3809115) 3809115..3809900 - 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -
N4686_RS18540 (3809872) 3809872..3811584 + 1713 Protein_3630 flagellar biosynthesis protein FlhA -
N4686_RS18545 (3811689) 3811689..3811967 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
N4686_RS18550 (3811960) 3811960..3812316 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
N4686_RS18555 (3812373) 3812373..3813146 - 774 WP_000543897.1 C40 family peptidase -
N4686_RS18560 (3813332) 3813332..3813592 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N4686_RS18565 (3813595) 3813595..3813873 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N4686_RS18570 (3814029) 3814029..3814769 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N4686_RS18575 (3814740) 3814740..3815507 - 768 WP_000333380.1 class II glutamine amidotransferase -
N4686_RS18580 (3815713) 3815713..3816291 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T278860 WP_000615976.1 NZ_CP123266:3813595-3813873 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT278860 WP_000729704.1 NZ_CP123266:3813332-3813592 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References