Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4673951..4674553 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag N4697_RS22505 Protein ID WP_000897305.1
Coordinates 4674242..4674553 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4697_RS22500 Protein ID WP_000356397.1
Coordinates 4673951..4674241 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS22475 (4669383) 4669383..4670018 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N4697_RS22480 (4670015) 4670015..4670944 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
N4697_RS22485 (4671457) 4671457..4672437 + 981 WP_000399648.1 IS110-like element IS621 family transposase -
N4697_RS22490 (4672667) 4672667..4672909 - 243 WP_001086388.1 protein YiiF -
N4697_RS22495 (4673128) 4673128..4673346 - 219 WP_001295676.1 CopG family transcriptional regulator -
N4697_RS22500 (4673951) 4673951..4674241 - 291 WP_000356397.1 NadS family protein Antitoxin
N4697_RS22505 (4674242) 4674242..4674553 - 312 WP_000897305.1 hypothetical protein Toxin
N4697_RS22510 (4674782) 4674782..4675690 + 909 WP_001162704.1 alpha/beta hydrolase -
N4697_RS22515 (4675754) 4675754..4676695 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N4697_RS22520 (4676740) 4676740..4677177 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N4697_RS22525 (4677174) 4677174..4678046 - 873 WP_000920762.1 virulence factor BrkB family protein -
N4697_RS22530 (4678040) 4678040..4678639 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4671457..4672437 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278837 WP_000897305.1 NZ_CP123260:c4674553-4674242 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278837 WP_000356397.1 NZ_CP123260:c4674241-4673951 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References