Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 645146..645945 Replicon chromosome
Accession NZ_CP123260
Organism Escherichia coli strain YZLc4-1

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag N4697_RS03155 Protein ID WP_000347267.1
Coordinates 645146..645610 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N4697_RS03160 Protein ID WP_001307405.1
Coordinates 645610..645945 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4697_RS03125 (640147) 640147..640581 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N4697_RS03130 (640599) 640599..641477 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
N4697_RS03135 (641467) 641467..642246 - 780 WP_063625504.1 PTS N-acetylgalactosamine transporter subunit IIC -
N4697_RS03140 (642257) 642257..642730 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N4697_RS03145 (642753) 642753..644033 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
N4697_RS03150 (644282) 644282..645091 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N4697_RS03155 (645146) 645146..645610 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N4697_RS03160 (645610) 645610..645945 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N4697_RS03165 (646094) 646094..647665 - 1572 WP_001273741.1 galactarate dehydratase -
N4697_RS03170 (648040) 648040..649374 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N4697_RS03175 (649390) 649390..650160 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T278820 WP_000347267.1 NZ_CP123260:c645610-645146 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278820 WP_001307405.1 NZ_CP123260:c645945-645610 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References