Detailed information of TA system TA027882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 396479..397178
• Replicon: plasmid pTM3
• Accession: NC_017958
• Organism: Tistrella mobilis KA081020-065

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: I3TW37
• Locus tag: TMO_RS25615
• Protein ID: WP_014747964.1
• Coordinates: 396479..396775 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: I3TW38
• Locus tag: TMO_RS25620
• Protein ID: WP_014747965.1
• Coordinates: 396777..397178 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TMO_RS25595	391939..392961	+	1023	WP_014747960.1	TRAP transporter substrate-binding protein DctP	-
TMO_RS25600	392966..393532	+	567	WP_014747961.1	TRAP transporter small permease	-
TMO_RS25605	393529..394812	+	1284	WP_014747962.1	TRAP transporter large permease	-
TMO_RS25610	394995..396287	+	1293	WP_014747963.1	MFS transporter	-
TMO_RS25615	396479..396775	+	297	WP_014747964.1	type II toxin-antitoxin system MqsR family toxin	Toxin
TMO_RS25620	396777..397178	+	402	WP_014747965.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
TMO_RS31420	397364..398224	+	861	WP_145978441.1	hypothetical protein	-
TMO_RS25625	398320..400032	-	1713	WP_051045652.1	AMP-binding protein	-
TMO_RS25630	400154..400912	+	759	WP_014747968.1	SDR family oxidoreductase	-
TMO_RS25635	400934..401659	+	726	WP_014747969.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..1126962	1126962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11138.74 Da
• Isoelectric Point: 6.9869

>T27882 WP_014747964.1 NC_017958:396479-396775 [Tistrella mobilis KA081020-065]
MEKWRPHHPLSLVQALALTGRFRMTGTARAGASRLLLDQQDVLDIVSQLAQGDFHKSMTTYADHTIWQDVYRPYTPAGHV
YLKLTVTDDLLIVSFNEV

Nucleotide

• Length: 297 bp

>T27882 NC_017958:396479-396775 [Tistrella mobilis KA081020-065]
ATGGAGAAGTGGCGGCCGCATCATCCGCTGAGCCTCGTGCAGGCGCTGGCCCTTACCGGCCGTTTTCGCATGACCGGCAC
GGCACGCGCTGGAGCGAGTCGTCTTCTGCTCGATCAGCAGGACGTCCTCGACATCGTAAGTCAGCTTGCACAGGGCGATT
TCCACAAGAGCATGACGACATATGCCGATCACACCATCTGGCAGGACGTGTACCGCCCTTATACCCCGGCGGGCCATGTC
TACCTGAAACTCACCGTCACCGACGATCTCCTCATCGTCTCGTTTAATGAGGTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14731.87 Da
• Isoelectric Point: 7.7018

>AT27882 WP_014747965.1 NC_017958:396777-397178 [Tistrella mobilis KA081020-065]
VKCPVCGAAELVHDTRDQTFTYKGETAVISRVVGDYCPACGESLTAPDETDRVMREMRDFMKQVNARAVDPSFITAVRKK
LALDQREAGRIFGGGVNAFSRYETGKAEPPVALVKLLRVLNRHPHLLDEVRAD

Nucleotide

• Length: 402 bp

>AT27882 NC_017958:396777-397178 [Tistrella mobilis KA081020-065]
GTGAAATGCCCTGTATGTGGCGCAGCCGAGCTTGTCCACGATACGCGCGACCAGACCTTCACCTATAAAGGCGAGACTGC
GGTCATCTCTCGGGTGGTGGGCGATTACTGCCCCGCCTGCGGTGAATCCCTCACTGCCCCGGACGAGACCGACCGGGTCA
TGCGCGAGATGCGCGACTTCATGAAGCAGGTGAATGCTCGTGCGGTCGACCCGTCCTTCATCACCGCCGTCCGCAAGAAG
CTGGCCCTGGATCAGCGCGAAGCCGGCAGGATCTTCGGCGGAGGCGTGAATGCGTTCTCGCGTTACGAAACCGGCAAGGC
AGAGCCCCCCGTCGCACTCGTGAAGCTCCTCCGCGTGCTCAATCGCCATCCACATCTGCTCGACGAAGTTCGCGCGGATT
GA

Structures

Toxin

• AlphaFold DB: I3TW37

Antitoxin

• AlphaFold DB: I3TW38