Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3826010..3826551 Replicon chromosome
Accession NZ_CP123255
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag N4680_RS18585 Protein ID WP_000615983.1
Coordinates 3826273..3826551 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag N4680_RS18580 Protein ID WP_000729703.1
Coordinates 3826010..3826270 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS18560 (3821685) 3821685..3822470 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
N4680_RS18565 (3822442) 3822442..3824154 + 1713 Protein_3633 flagellar biosynthesis protein FlhA -
N4680_RS18570 (3824378) 3824378..3824875 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
N4680_RS18575 (3825051) 3825051..3825800 - 750 WP_000056849.1 C40 family peptidase -
N4680_RS18580 (3826010) 3826010..3826270 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N4680_RS18585 (3826273) 3826273..3826551 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N4680_RS18590 (3826707) 3826707..3827447 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N4680_RS18595 (3827418) 3827418..3828185 - 768 WP_000333380.1 class II glutamine amidotransferase -
N4680_RS18600 (3828391) 3828391..3828969 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T278810 WP_000615983.1 NZ_CP123255:3826273-3826551 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT278810 WP_000729703.1 NZ_CP123255:3826010-3826270 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References