Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1852313..1852815 Replicon chromosome
Accession NZ_CP123255
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag N4680_RS08820 Protein ID WP_000767832.1
Coordinates 1852561..1852815 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N4680_RS08815 Protein ID WP_001259255.1
Coordinates 1852313..1852564 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS08790 (1847491) 1847491..1848558 - 1068 WP_000080064.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N4680_RS08795 (1848558) 1848558..1849628 - 1071 WP_094336856.1 histidinol-phosphate transaminase -
N4680_RS08800 (1849625) 1849625..1850929 - 1305 WP_024198577.1 histidinol dehydrogenase -
N4680_RS08805 (1850935) 1850935..1851834 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N4680_RS08810 (1851980) 1851980..1852030 - 51 WP_001364200.1 his operon leader peptide -
N4680_RS08815 (1852313) 1852313..1852564 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N4680_RS08820 (1852561) 1852561..1852815 + 255 WP_000767832.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N4680_RS08825 (1852898) 1852898..1853722 + 825 WP_000754737.1 SDR family oxidoreductase -
N4680_RS08830 (1853768) 1853768..1854697 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
N4680_RS08835 (1854911) 1854911..1854973 + 63 WP_097433929.1 membrane protein YoeI -
N4680_RS08840 (1854963) 1854963..1856321 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10232.66 Da        Isoelectric Point: 8.0280

>T278801 WP_000767832.1 NZ_CP123255:1852561-1852815 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT278801 WP_001259255.1 NZ_CP123255:1852313-1852564 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References