Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 603645..604444 Replicon chromosome
Accession NZ_CP123255
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name yhaV Uniprot ID D3GWU5
Locus tag N4680_RS02945 Protein ID WP_000347272.1
Coordinates 603645..604109 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N4680_RS02950 Protein ID WP_001307405.1
Coordinates 604109..604444 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS02915 (598646) 598646..599080 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N4680_RS02920 (599098) 599098..599976 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
N4680_RS02925 (599966) 599966..600745 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N4680_RS02930 (600756) 600756..601229 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N4680_RS02935 (601252) 601252..602532 - 1281 Protein_574 tagatose-bisphosphate aldolase subunit KbaZ -
N4680_RS02940 (602781) 602781..603590 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
N4680_RS02945 (603645) 603645..604109 - 465 WP_000347272.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N4680_RS02950 (604109) 604109..604444 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N4680_RS02955 (604593) 604593..606164 - 1572 WP_001273738.1 galactarate dehydratase -
N4680_RS02960 (606539) 606539..607873 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
N4680_RS02965 (607889) 607889..608659 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 603645..615097 11452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17832.26 Da        Isoelectric Point: 9.6924

>T278795 WP_000347272.1 NZ_CP123255:c604109-603645 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278795 WP_001307405.1 NZ_CP123255:c604444-604109 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829KUD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References