Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4612294..4612896 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag N4691_RS21880 Protein ID WP_000897305.1
Coordinates 4612585..4612896 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4691_RS21875 Protein ID WP_000356397.1
Coordinates 4612294..4612584 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS21850 (4608238) 4608238..4609140 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N4691_RS21855 (4609137) 4609137..4609772 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N4691_RS21860 (4609769) 4609769..4610698 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
N4691_RS21865 (4611028) 4611028..4611270 - 243 WP_001087409.1 protein YiiF -
N4691_RS21870 (4611490) 4611490..4611708 - 219 WP_001315930.1 CopG family transcriptional regulator -
N4691_RS21875 (4612294) 4612294..4612584 - 291 WP_000356397.1 NadS family protein Antitoxin
N4691_RS21880 (4612585) 4612585..4612896 - 312 WP_000897305.1 hypothetical protein Toxin
N4691_RS21885 (4613125) 4613125..4614033 + 909 WP_001162704.1 alpha/beta hydrolase -
N4691_RS21890 (4614097) 4614097..4615038 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N4691_RS21895 (4615083) 4615083..4615520 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N4691_RS21900 (4615517) 4615517..4616389 - 873 WP_000920762.1 virulence factor BrkB family protein -
N4691_RS21905 (4616383) 4616383..4616982 - 600 WP_001295269.1 glucose-1-phosphatase -
N4691_RS21910 (4617081) 4617081..4617866 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278774 WP_000897305.1 NZ_CP123244:c4612896-4612585 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278774 WP_000356397.1 NZ_CP123244:c4612584-4612294 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References