Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3782675..3783216 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag N4691_RS18045 Protein ID WP_000615980.1
Coordinates 3782938..3783216 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag N4691_RS18040 Protein ID WP_000729709.1
Coordinates 3782675..3782935 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS18025 (3778757) 3778757..3780850 + 2094 WP_021556448.1 flagellar biosynthesis protein FlhA -
N4691_RS18030 (3781043) 3781043..3781540 - 498 WP_021556447.1 REP-associated tyrosine transposase RayT -
N4691_RS18035 (3781716) 3781716..3782465 - 750 WP_106510008.1 C40 family peptidase -
N4691_RS18040 (3782675) 3782675..3782935 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N4691_RS18045 (3782938) 3782938..3783216 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N4691_RS18050 (3783372) 3783372..3784112 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N4691_RS18055 (3784083) 3784083..3784850 - 768 WP_000333379.1 class II glutamine amidotransferase -
N4691_RS18060 (3785056) 3785056..3785634 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3781716..3791468 9752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T278770 WP_000615980.1 NZ_CP123244:3782938-3783216 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT278770 WP_000729709.1 NZ_CP123244:3782675-3782935 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References