Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 635652..636451 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name yhaV Uniprot ID A0A161R7C1
Locus tag N4691_RS03060 Protein ID WP_000347278.1
Coordinates 635652..636116 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N4691_RS03065 Protein ID WP_001307405.1
Coordinates 636116..636451 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS03030 (630653) 630653..631087 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N4691_RS03035 (631105) 631105..631983 - 879 WP_021557244.1 PTS N-acetylgalactosamine transporter subunit IID -
N4691_RS03040 (631973) 631973..632752 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N4691_RS03045 (632763) 632763..633236 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N4691_RS03050 (633259) 633259..634539 - 1281 WP_021557243.1 tagatose-bisphosphate aldolase subunit KbaZ -
N4691_RS03055 (634788) 634788..635597 + 810 WP_000072174.1 aga operon transcriptional regulator AgaR -
N4691_RS03060 (635652) 635652..636116 - 465 WP_000347278.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N4691_RS03065 (636116) 636116..636451 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N4691_RS03070 (636600) 636600..638171 - 1572 WP_001273763.1 galactarate dehydratase -
N4691_RS03075 (638546) 638546..639880 + 1335 WP_000599633.1 galactarate/glucarate/glycerate transporter GarP -
N4691_RS03080 (639896) 639896..640666 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17866.28 Da        Isoelectric Point: 9.6924

>T278759 WP_000347278.1 NZ_CP123244:c636116-635652 [Escherichia coli]
MDFPQRVNGWALYTHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278759 WP_001307405.1 NZ_CP123244:c636451-636116 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161R7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References