Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2045468..2045970 Replicon chromosome
Accession NZ_CP123240
Organism Escherichia coli strain YZLc1-3

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag N4725_RS09860 Protein ID WP_000767820.1
Coordinates 2045716..2045970 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N4725_RS09855 Protein ID WP_001259255.1
Coordinates 2045468..2045719 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4725_RS09830 (2040646) 2040646..2041713 - 1068 WP_001513846.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N4725_RS09835 (2041713) 2041713..2042783 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
N4725_RS09840 (2042780) 2042780..2044084 - 1305 WP_096788178.1 histidinol dehydrogenase -
N4725_RS09845 (2044090) 2044090..2044989 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N4725_RS09850 (2045135) 2045135..2045185 - 51 WP_001364200.1 his operon leader peptide -
N4725_RS09855 (2045468) 2045468..2045719 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N4725_RS09860 (2045716) 2045716..2045970 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N4725_RS09865 (2046053) 2046053..2046877 + 825 WP_000754756.1 SDR family oxidoreductase -
N4725_RS09870 (2046923) 2046923..2047852 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N4725_RS09875 (2048067) 2048067..2048129 + 63 WP_010723108.1 membrane protein YoeI -
N4725_RS09880 (2048119) 2048119..2049477 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N4725_RS09885 (2049656) 2049656..2050714 + 1059 WP_033547227.1 thiosulfate utilization transporter TsuA/YeeE -
N4725_RS09890 (2050728) 2050728..2050955 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T278732 WP_000767820.1 NZ_CP123240:2045716-2045970 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT278732 WP_001259255.1 NZ_CP123240:2045468-2045719 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References