Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3710013..3710554 Replicon chromosome
Accession NZ_CP123237
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QET42_RS18340 Protein ID WP_000615983.1
Coordinates 3710276..3710554 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QET42_RS18335 Protein ID WP_000729703.1
Coordinates 3710013..3710273 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET42_RS18315 (3705688) 3705688..3706473 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QET42_RS18320 (3706445) 3706445..3708157 + 1713 Protein_3585 flagellar biosynthesis protein FlhA -
QET42_RS18325 (3708381) 3708381..3708878 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QET42_RS18330 (3709054) 3709054..3709803 - 750 WP_000056849.1 C40 family peptidase -
QET42_RS18335 (3710013) 3710013..3710273 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QET42_RS18340 (3710276) 3710276..3710554 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QET42_RS18345 (3710710) 3710710..3711450 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QET42_RS18350 (3711421) 3711421..3712188 - 768 WP_000333380.1 class II glutamine amidotransferase -
QET42_RS18355 (3712394) 3712394..3712972 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA / hcp2/tssD2 / tssB / tssC / IlpA 3704562..3758448 53886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T278717 WP_000615983.1 NZ_CP123237:3710276-3710554 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT278717 WP_000729703.1 NZ_CP123237:3710013-3710273 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References