Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3703816..3704510 Replicon chromosome
Accession NZ_CP123237
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name yafO Uniprot ID Q47157
Locus tag QET42_RS18300 Protein ID WP_001263489.1
Coordinates 3703816..3704214 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag QET42_RS18305 Protein ID WP_000554758.1
Coordinates 3704217..3704510 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3699404) 3699404..3699484 - 81 NuclAT_10 - -
- (3699404) 3699404..3699484 - 81 NuclAT_10 - -
- (3699404) 3699404..3699484 - 81 NuclAT_10 - -
- (3699404) 3699404..3699484 - 81 NuclAT_10 - -
QET42_RS18275 (3700080) 3700080..3700538 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QET42_RS18280 (3700799) 3700799..3702256 + 1458 WP_001292994.1 cytosol nonspecific dipeptidase -
QET42_RS18285 (3702313) 3702313..3702834 - 522 Protein_3578 peptide chain release factor H -
QET42_RS18290 (3702830) 3702830..3703036 - 207 Protein_3579 RtcB family protein -
QET42_RS18295 (3703354) 3703354..3703806 - 453 WP_001059892.1 GNAT family N-acetyltransferase -
QET42_RS18300 (3703816) 3703816..3704214 - 399 WP_001263489.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QET42_RS18305 (3704217) 3704217..3704510 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QET42_RS18310 (3704562) 3704562..3705617 - 1056 WP_001226164.1 DNA polymerase IV -
QET42_RS18315 (3705688) 3705688..3706473 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QET42_RS18320 (3706445) 3706445..3708157 + 1713 Protein_3585 flagellar biosynthesis protein FlhA -
QET42_RS18325 (3708381) 3708381..3708878 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15487.84 Da        Isoelectric Point: 7.4215

>T278716 WP_001263489.1 NZ_CP123237:c3704214-3703816 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT278716 WP_000554758.1 NZ_CP123237:c3704510-3704217 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090J8B1

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References