Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4765981..4766583 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QET41_RS23225 Protein ID WP_000897302.1
Coordinates 4766272..4766583 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QET41_RS23220 Protein ID WP_000356397.1
Coordinates 4765981..4766271 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS23195 (4762054) 4762054..4762956 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QET41_RS23200 (4762953) 4762953..4763588 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QET41_RS23205 (4763585) 4763585..4764514 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QET41_RS23210 (4764730) 4764730..4764948 - 219 WP_001314326.1 CopG family transcriptional regulator -
QET41_RS23215 (4765344) 4765344..4765622 - 279 WP_001296612.1 hypothetical protein -
QET41_RS23220 (4765981) 4765981..4766271 - 291 WP_000356397.1 NadS family protein Antitoxin
QET41_RS23225 (4766272) 4766272..4766583 - 312 WP_000897302.1 hypothetical protein Toxin
QET41_RS23230 (4766812) 4766812..4767720 + 909 WP_001774092.1 alpha/beta hydrolase -
QET41_RS23235 (4767784) 4767784..4768725 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QET41_RS23240 (4768770) 4768770..4769207 - 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
QET41_RS23245 (4769204) 4769204..4770076 - 873 WP_000920762.1 virulence factor BrkB family protein -
QET41_RS23250 (4770070) 4770070..4770669 - 600 WP_001314324.1 glucose-1-phosphatase -
QET41_RS23255 (4770768) 4770768..4771553 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T278693 WP_000897302.1 NZ_CP123231:c4766583-4766272 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278693 WP_000356397.1 NZ_CP123231:c4766271-4765981 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References