Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1898427..1898929 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QET41_RS08960 Protein ID WP_000767822.1
Coordinates 1898675..1898929 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QET41_RS08955 Protein ID WP_001259255.1
Coordinates 1898427..1898678 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS08930 (1893605) 1893605..1894672 - 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QET41_RS08935 (1894672) 1894672..1895742 - 1071 WP_001538918.1 histidinol-phosphate transaminase -
QET41_RS08940 (1895739) 1895739..1897043 - 1305 WP_001445483.1 histidinol dehydrogenase -
QET41_RS08945 (1897049) 1897049..1897948 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
QET41_RS08950 (1898094) 1898094..1898144 - 51 WP_001364200.1 his operon leader peptide -
QET41_RS08955 (1898427) 1898427..1898678 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QET41_RS08960 (1898675) 1898675..1898929 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QET41_RS08965 (1899012) 1899012..1899836 + 825 WP_000754737.1 SDR family oxidoreductase -
QET41_RS08970 (1899882) 1899882..1900811 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QET41_RS08975 (1901026) 1901026..1901088 + 63 WP_010723108.1 membrane protein YoeI -
QET41_RS08980 (1901078) 1901078..1902436 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T278675 WP_000767822.1 NZ_CP123231:1898675-1898929 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT278675 WP_001259255.1 NZ_CP123231:1898427-1898678 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References