27866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1855564..1856083 Replicon chromosome
Accession NC_017950
Organism Streptococcus suis ST1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4V0ELL3
Locus tag SSUST1_RS09255 Protein ID WP_014736467.1
Coordinates 1855564..1855821 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4V0EL70
Locus tag SSUST1_RS09260 Protein ID WP_014736468.1
Coordinates 1855823..1856083 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUST1_RS09240 1852032..1853762 - 1731 WP_014736464.1 membrane protein -
SSUST1_RS09245 1854125..1854997 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSUST1_RS09250 1855016..1855546 - 531 WP_014736466.1 DUF1697 domain-containing protein -
SSUST1_RS09255 1855564..1855821 - 258 WP_014736467.1 Txe/YoeB family addiction module toxin Toxin
SSUST1_RS09260 1855823..1856083 - 261 WP_014736468.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SSUST1_RS09265 1856159..1856614 - 456 WP_014736469.1 8-oxo-dGTP diphosphatase -
SSUST1_RS09270 1856618..1856986 - 369 WP_014736470.1 hypothetical protein -
SSUST1_RS09275 1856979..1857546 - 568 Protein_1765 ribonuclease M5 -
SSUST1_RS09280 1857530..1858312 - 783 WP_014736471.1 TatD family hydrolase -
SSUST1_RS09285 1858419..1858556 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSUST1_RS09290 1858724..1859719 - 996 WP_014736472.1 protein jag -
SSUST1_RS09295 1859739..1860551 - 813 WP_014736473.1 YidC/Oxa1 family membrane protein insertase -
SSUST1_RS09300 1860535..1860894 - 360 WP_014736474.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10309.77 Da        Isoelectric Point: 7.3118

>T27866 WP_014736467.1 NC_017950:c1855821-1855564 [Streptococcus suis ST1]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYKGAWSRRIDAENRLIYMVETDQLYILSL
KDHYG

Download         Length: 258 bp

>T27866 NC_017950:c1855821-1855564 [Streptococcus suis ST1]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAACGACACCCGTTTGAAGGTATTGCCAAGCCAGAACCTTTGAAGTATGATTATAAGG
GAGCCTGGTCGAGACGGATTGATGCTGAGAATCGGTTGATTTATATGGTAGAAACCGACCAGTTGTATATCTTGTCGCTG
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9931.25 Da        Isoelectric Point: 5.1100

>AT27866 WP_014736468.1 NC_017950:c1856083-1855823 [Streptococcus suis ST1]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQEH
NLIEAD

Download         Length: 261 bp

>AT27866 NC_017950:c1856083-1855823 [Streptococcus suis ST1]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTTTTGCGTGGTATGGCTCAAGTCAAAGCTGGACAAACCCAAGAACAC
AATCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0ELL3

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0EL70

References