Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4124046..4124647 Replicon chromosome
Accession NC_017933
Organism Cronobacter sakazakii ES15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ES15_RS19045 Protein ID WP_014729860.1
Coordinates 4124336..4124647 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ES15_RS19040 Protein ID WP_007871962.1
Coordinates 4124046..4124336 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES15_RS19025 4121513..4122415 + 903 WP_004385164.1 formate dehydrogenase subunit beta -
ES15_RS19030 4122412..4123047 + 636 WP_014729858.1 formate dehydrogenase cytochrome b556 subunit -
ES15_RS19035 4123044..4123973 + 930 WP_014729859.1 formate dehydrogenase accessory protein FdhE -
ES15_RS19040 4124046..4124336 - 291 WP_007871962.1 helix-turn-helix domain-containing protein Antitoxin
ES15_RS19045 4124336..4124647 - 312 WP_014729860.1 hypothetical protein Toxin
ES15_RS19050 4124822..4125646 - 825 WP_014729861.1 AraC family transcriptional regulator -
ES15_RS19055 4125907..4127310 + 1404 WP_014729862.1 MFS transporter -
ES15_RS19060 4127322..4129289 + 1968 WP_014729863.1 glycoside hydrolase family 127 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12041.01 Da        Isoelectric Point: 10.0150

>T27863 WP_014729860.1 NC_017933:c4124647-4124336 [Cronobacter sakazakii ES15]
MLFIETEIFTRAVTALLSDDDYQRLQWFLALRPDYGDVIPDTGGLRKARWLAGGRGKRGGVRIIYFYRVAADEIRLLLIY
RKGIKDDLSPHEKAVLRMLNERW

Download         Length: 312 bp

>T27863 NC_017933:c4124647-4124336 [Cronobacter sakazakii ES15]
ATGCTCTTCATTGAAACGGAAATCTTTACCCGGGCCGTGACCGCCCTGCTTAGCGATGACGATTACCAGCGGTTGCAGTG
GTTCCTGGCCCTGCGACCCGATTACGGTGATGTTATCCCGGATACCGGCGGGCTTCGTAAAGCTCGCTGGCTTGCAGGCG
GACGGGGCAAACGAGGCGGCGTCAGGATCATCTATTTTTATCGCGTTGCTGCCGATGAAATCCGCCTGCTGCTGATTTAT
CGCAAGGGGATAAAAGACGATCTCTCGCCTCACGAAAAAGCCGTGCTCAGAATGCTGAATGAGAGGTGGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10659.23 Da        Isoelectric Point: 10.7279

>AT27863 WP_007871962.1 NC_017933:c4124336-4124046 [Cronobacter sakazakii ES15]
MDKALFEQLTESLRQMNDISEGRREPSRVFVIDALKIKAIREASGLSQTKFASLISVSVDTLRNWEQGRRSPTGPARALL
RAIANDPQHVLSALAL

Download         Length: 291 bp

>AT27863 NC_017933:c4124336-4124046 [Cronobacter sakazakii ES15]
ATGGACAAGGCGCTGTTTGAACAGTTAACCGAAAGCCTGCGGCAGATGAATGATATCAGCGAAGGCCGCCGAGAGCCCTC
ACGGGTTTTTGTTATCGACGCGCTGAAAATAAAAGCGATCAGAGAGGCATCAGGCCTTTCTCAGACGAAATTCGCCAGCC
TGATTTCAGTAAGTGTGGATACGCTGCGTAACTGGGAGCAGGGAAGGCGCTCGCCGACCGGGCCTGCGCGCGCGCTGTTG
CGTGCGATTGCGAACGATCCGCAGCATGTTCTCTCTGCGCTGGCGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References