Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 255391..256084 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag PAE60_RS02405 Protein ID WP_000415585.1
Coordinates 255391..255687 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PAE60_RS02410 Protein ID WP_000650107.1
Coordinates 255689..256084 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS02370 (250525) 250525..251004 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
PAE60_RS02375 (251007) 251007..251717 + 711 WP_000834030.1 hypothetical protein -
PAE60_RS02380 (251724) 251724..252056 + 333 WP_000914690.1 DUF2645 family protein -
PAE60_RS02385 (252102) 252102..253451 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
PAE60_RS02390 (253448) 253448..254107 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
PAE60_RS02395 (254259) 254259..254651 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PAE60_RS02400 (254704) 254704..255186 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PAE60_RS02405 (255391) 255391..255687 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
PAE60_RS02410 (255689) 255689..256084 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PAE60_RS02415 (256217) 256217..257824 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
PAE60_RS02420 (257962) 257962..260220 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T278617 WP_000415585.1 NZ_CP123197:255391-255687 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT278617 WP_000650107.1 NZ_CP123197:255689-256084 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References